A longitudinal MRI study of histopathologically defined hypointense multiple sclerosis lesions

被引：161

作者：

Bitsch, A

Kuhlmann, T

Stadelmann, C

Lassmann, H

Lucchinetti, C

Brück, W

机构：

[1] Univ Gottingen, Abt Neurol, Gottingen, Germany

[2] Charite, Inst Neuropathol, D-13353 Berlin, Germany

[3] Inst Hirnforsch, Abt Neuroimmunol, Vienna, Austria

[4] Mayo Clin & Mayo Fdn, Dept Neurol, Rochester, MN 55905 USA

来源：

ANNALS OF NEUROLOGY | 2001年 / 49卷 / 06期

关键词：

D O I：

10.1002/ana.1053

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Severe tissue destruction is the presumed histopathological correlate of hypointense multiple sclerosis (MS) lesions. In this study we correlated changes of lesion hypointensity over time with initial histopathological features in 14 biopsied MS lesions. The extent of hypointensity increased in initially demyelinated plaques and decreased in remyelinating lesions. The initial axonal loss determined the increase of hypointensity over time. In conclusion, both axonal loss and demyelinating activity determine the evolution of hypointensity over time.

引用

收藏

页码：793 / 796

页数：4

相关论文

共 21 条

[1] Acute axonal injury in multiple sclerosis -: Correlation with demyelination and inflammation [J].

Bitsch, A ;

Schuchardt, J ;

Bunkowski, S ;

Kuhlmann, T ;

Brück, W .

BRAIN, 2000, 123 :1174-1183

[2] Inflammatory central nervous system demyelination: Correlation of magnetic resonance imaging findings with lesion pathology [J].

Bruck, W ;

Bitsch, A ;

Kolenda, H ;

Bruck, Y ;

Stiefel, M ;

Lassmann, H .

ANNALS OF NEUROLOGY, 1997, 42 (05) :783-793

[3] MONOCYTE-MACROPHAGE DIFFERENTIATION IN EARLY MULTIPLE-SCLEROSIS LESIONS [J].

BRUCK, W ;

PORADA, P ;

POSER, S ;

RIECKMANN, P ;

HANEFELD, F ;

KRETZSCHMAR, HA ;

LASSMANN, H .

ANNALS OF NEUROLOGY, 1995, 38 (05) :788-796

[4] Axonal damage correlates with disability in patients with relapsing-remitting multiple sclerosis - Results of a longitudinal magnetic resonance spectroscopy study [J].

De Stefano, N ;

Matthews, PM ;

Fu, LQ ;

Narayanan, S ;

Stanley, J ;

Francis, GS ;

Antel, JP ;

Arnold, DL .

BRAIN, 1998, 121 :1469-1477

[5] Correlation of magnetic resonance imaging parameters with clinical disability in multiple sclerosis: a preliminary study [J].

Grimaud, J ;

Barker, GJ ;

Wang, L ;

Lai, M ;

MacManus, DG ;

Webb, SL ;

Thompson, AJ ;

McDonald, WI ;

Tofts, PS ;

Miller, DH .

JOURNAL OF NEUROLOGY, 1999, 246 (10) :961-967

[6] Remyelination in multiple sclerosis [J].

Lassmann, H ;

Bruck, W ;

Lucchinetti, C ;

Rodriguez, M .

MULTIPLE SCLEROSIS JOURNAL, 1997, 3 (02) :133-136

[7]

LOEVNER LA, 1995, AM J NEURORADIOL, V16, P1473

[8] MULTIPLE-SCLEROSIS - HISTOPATHOLOGIC AND MR AND OR CT CORRELATION IN 37 CASES AT BIOPSY AND 3 CASES AT AUTOPSY [J].

NESBIT, GM ;

FORBES, GS ;

SCHEITHAUER, BW ;

OKAZAKI, H ;

RODRIGUEZ, M .

RADIOLOGY, 1991, 180 (02) :467-474

[9] NEW DIAGNOSTIC-CRITERIA FOR MULTIPLE-SCLEROSIS - GUIDELINES FOR RESEARCH PROTOCOLS [J].

POSER, CM ;

PATY, DW ;

SCHEINBERG, L ;

MCDONALD, WI ;

DAVIS, FA ;

EBERS, GC ;

JOHNSON, KP ;

SIBLEY, WA ;

SILBERBERG, DH ;

TOURTELLOTTE, WW .

ANNALS OF NEUROLOGY, 1983, 13 (03) :227-231

[10] MULTIPLE-SCLEROSIS - REMYELINATION OF NASCENT LESIONS [J].

PRINEAS, JW ;

BARNARD, RO ;

KWON, EE ;

SHARER, LR ;

CHO, ES .

ANNALS OF NEUROLOGY, 1993, 33 (02) :137-151