Mechanisms for complexity in the brain: generating the insect central complex

被引:49
作者
Boyan, George S. [2 ]
Reichert, Heinrich [1 ]
机构
[1] Univ Basel, Biozentrum, CH-4056 Basel, Switzerland
[2] Univ Munich, Bioctr, D-82152 Martinsried, Germany
基金
瑞士国家科学基金会;
关键词
GRASSHOPPER SCHISTOCERCA-GREGARIA; AMPLIFYING NEUROBLAST LINEAGES; INTERMEDIATE PROGENITOR CELLS; REGULATES SELF-RENEWAL; CENTRAL-NERVOUS-SYSTEM; ASYMMETRIC DIVISION; ELLIPSOID BODY; EARLY NEUROGENESIS; TUMOR-SUPPRESSOR; DROSOPHILA BRAIN;
D O I
10.1016/j.tins.2011.02.002
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The central complex of the insect brain is a remarkably miniaturized but highly complex multimodal information-processing network. Recent work on central complex development in Drosophila and grasshopper reveals that the cells comprising its complex circuitry are generated by a surprisingly small number of primary progenitors. Of these, four identified neural stem cells generate a large number of neurons through a novel mode of neurogenesis that involves self-renewing intermediate progenitor cells. Interestingly, a comparable mode of amplification of proliferation also operates in the developing mammalian cortex; this could be a general strategy for increasing brain size and complexity. Although this type of proliferation generates a large number of progeny, it is also prone to dysregulation, resulting in brain tumors. Thus, furthering our knowledge of the development of the central complex is likely to be valuable not only for understanding brain complexity but could also have important implications for identifying developmental pathways that go awry during tumor formation.
引用
收藏
页码:247 / 257
页数:11
相关论文
共 79 条
[1]  
[Anonymous], 1976, ATLAS INSECT BRAIN, DOI DOI 10.1007/978-3-642-66179-2
[2]   Drosophila type II neuroblast lineages keep Prospero levels low to generate large clones that contribute to the adult brain central complex [J].
Bayraktar, Omer Ali ;
Boone, Jason Q. ;
Drummond, Michael L. ;
Doe, Chris Q. .
NEURAL DEVELOPMENT, 2010, 5
[3]   The brain tumor gene negatively regulates neural progenitor cell proliferation in the larval central brain of Drosophila [J].
Bello, Bruno ;
Reichert, Heinrich ;
Hirth, Frank .
DEVELOPMENT, 2006, 133 (14) :2639-2648
[4]   Amplification of neural stem cell proliferation by intermediate progenitor cells in Drosophila brain development [J].
Bello, Bruno C. ;
Izergina, Natalya ;
Caussinus, Emmanuel ;
Reichert, Heinrich .
NEURAL DEVELOPMENT, 2008, 3 (1)
[5]   Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells [J].
Betschinger, J ;
Mechtler, K ;
Knoblich, JA .
CELL, 2006, 124 (06) :1241-1253
[6]   Identification of Drosophila type II neuroblast lineages containing transit amplifying ganglion mother cells [J].
Boone, Jason Q. ;
Doe, Chris Q. .
DEVELOPMENTAL NEUROBIOLOGY, 2008, 68 (09) :1185-1195
[7]   The tumor suppressors brat and numb regulate transit-amplifying neuroblast lineages in Drosophila [J].
Bowman, Sarah K. ;
Rolland, Vivien ;
Betschinger, Joerg ;
Kinsey, Kaolin A. ;
Emery, Gregory ;
Knoblich, Juergen A. .
DEVELOPMENTAL CELL, 2008, 14 (04) :535-546
[8]   An ontogenetic analysis of locustatachykinin-like expression in the central complex of the grasshopper Schistocerca gregaria [J].
Boyan, G. S. ;
Williams, J. L. D. ;
Herbert, Z. .
ARTHROPOD STRUCTURE & DEVELOPMENT, 2008, 37 (06) :480-491
[9]   Proliferative cell types in embryonic lineages of the central complex of the grasshopper Schistocerca gregaria [J].
Boyan, George ;
Williams, Leslie ;
Legl, Andrea ;
Herbert, Zsofia .
CELL AND TISSUE RESEARCH, 2010, 341 (02) :259-277
[10]   Embryonic development of the pars intercerebralis central complex of the grasshopper [J].
Boyan, GS ;
Williams, JLD .
DEVELOPMENT GENES AND EVOLUTION, 1997, 207 (05) :317-329