Genetic deficiency of chemokine receptor CCR5 is a strong risk factor for symptomatic West Nile Virus infection: A meta-analysis of 4 cohorts in the US epidemic

被引：154

作者：

Lim, Jean K. ^{[1
]}

Louie, Christine Y. ^{[1
]}

Glaser, Carol ^{[2
]}

Jean, Cynthia ^{[2
]}

Johnson, Bernard ^{[3
]}

Johnson, Hope ^{[3
]}

McDermott, David H. ^{[1
]}

Murphy, Philip M. ^{[1
]}

机构：

[1] NIAID, Mol Signaling Sect, Lab Mol Immunol, Natl Inst Hlth, Bethesda, MD 20892 USA

[2] Calif Dept Hlth Serv, Viral & Rickettsial Dis Lab, Richmond, CA USA

[3] Illinois Dept Publ Hlth, Div Labs, Chicago, IL USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2008年 / 197卷 / 02期

关键词：

D O I：

10.1086/524691

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

West Nile virus (WNV) causes disease in similar to 20% of infected humans. We previously reported that homozygosity for CCR5 Delta 32, a nonfunctional variant of chemokine receptor CCR5, is markedly increased among symptomatic WNV-seropositive patients from Arizona and Colorado. To confirm this, we analyzed cohorts from California and Illinois. An increase in CCR5-deficient subjects was found in both (for California, , lodds ratio [OR], 4.2 [95% confidence interval {CI}, 1.5-11.9] [P= .004]; for Illinois, OR, 3.1 [95% CI, 0.9-11.2] [P = .06]). A meta-analysis of all 4 cohorts showed an OR of 4.2 (95% CI, 2.1-8.3 [P < .0001]). Thus, CCR5 deficiency is a strong and consistent risk factor for symptomatic WNV infection in the United States.

引用

页码：262 / 265

页数：4

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