H2O2-induced platelet aggregation and increase in intracellular Ca2+ concentration are blocked by inhibitors of intracellular signaling

被引：9

作者：

Loiko, EN

Samal, AB

Shulyakovskaya, SM

机构：

[1] Belarusian State Univ, Dept Biophys, Minsk 220050, BELARUS

[2] Natl Acad Sci Belarus, Inst Bioorgan Chem, Minsk 220141, BELARUS

来源：

BIOCHEMISTRY-MOSCOW | 2003年 / 68卷 / 11期

关键词：

hydrogen peroxide; platelets; platelet aggregation; intracellular Ca2+ cAMP; cGMP; inhibitors; ADP arachidonic acid;

D O I：

10.1023/B:BIRY.0000009135.85883.65

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inhibitors of signaling enzymes such as guanosine-5'-O-2-thiodiphosphate, aristolochic acid, aspirin, indomethacin, and trifluoperazine block H2O2-induced platelet aggregation and H2O2-induced increase in the intracellular concentration of Ca2+. These findings suggest that the effect of H2O2 on platelets is associated with activation of signal pathways responsible for increase in the concentration of intracellular Ca2+. On H2O2-induced platelet aggregation, the concentration of cAMP in the cytoplasm decreases and that of cGMP increases.

引用

收藏

页码：1210 / 1216

页数：7

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