Reference ranges for serum S100B protein during the first three years of life

被引：41

作者：

Bouvier, Damien ^{[1
]}

Castellani, Christoph ^{[2
]}

Fournier, Mathilde ^{[1
]}

Dauphin, Jean-Benoit ^{[3
]}

Ughetto, Sylvie ^{[4
]}

Breton, Mathias ^{[4
]}

Labbe, Andre ^{[3
]}

Weinberg, Annelie-Martina ^{[2
]}

Sapin, Vincent ^{[1
]}

机构：

[1] Clermont Ferrand Teaching Hosp, Dept Biochem, Clermont Ferrand, France

[2] Graz Med Univ, Dept Paediat & Adolescent Surg, Graz, Austria

[3] Clermont Ferrand Teaching Hosp, Dept Paediat Emergency, Clermont Ferrand, France

[4] Clermont Ferrand Teaching Hosp, Dept Med Informat, Clermont Ferrand, France

来源：

CLINICAL BIOCHEMISTRY | 2011年 / 44卷 / 10-11期

关键词：

S100B; Children; Reference ranges; TRAUMATIC BRAIN-INJURY; DELIVERY; CHILDREN; BLOOD; SEX;

D O I：

10.1016/j.clinbiochem.2011.05.004

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Objective: Clinical and diagnostic management of traumatic brain injuries is problematic in young children. To facilitate this management, we describe blood reference ranges for the well established biomarker S100B in children younger than 3 years. Design and methods: Serum S100B concentrations were determined by electro-chemiluminescence immunoassay in a population of 186 healthy children aged 0-3 years. Results: Four age groups emerged, i.e. 0-3, 4-9, 10-24 and 25-36 months. We also found an interesting inverse correlation with head circumference. Conclusion: This study provides useful serum S100B values from the largest cohort of healthy children aged 0-3 years old. (C) 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：927 / 929

页数：3

共 12 条

[1] Multicenter evaluation of the analytical and clinical performance of the Elecsys® S100 immunoassay in patients with malignant melanoma [J].

Alber, B ;

Hein, R ;

Garbe, C ;

Caroli, U ;

Luppa, PB .

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2005, 43 (05) :557-563

[2] Brain-specific NSE and S-100 proteins in umbilical blood after normal delivery [J].

Amer-Wåhlin, I ;

Herbst, A ;

Lindoff, C ;

Thorngren-Jerneck, K ;

Marsál, K ;

Alling, C .

CLINICA CHIMICA ACTA, 2001, 304 (1-2) :57-63

[3] Neuroprotein s-100B-a useful parameter in paediatric patients with mild traumatic brain injury? [J].

Castellani, C. ;

Bimbashi, P. ;

Ruttenstock, E. ;

Sacherer, P. ;

Stojakovic, T. ;

Weinberg, A-M .

ACTA PAEDIATRICA, 2009, 98 (10) :1607-1612

[4] Reference ranges for neuroprotein S-100B: from infants to adolescents [J].

Castellani, Christoph ;

Stojakovic, Tatjana ;

Cichocki, Martin ;

Scharnagl, Hubert ;

Erwa, Wolfgang ;

Gutmann, Anton ;

Weinberg, Annelie-Martina .

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2008, 46 (09) :1296-1299

[5]

CHEN C, 2007, P 30 ANN SAS US GROU

[6] Role of the S100B serum biomarker in the treatment of children suffering from mild traumatic brain injury [J].

Filippidis, Aristotelis S. ;

Papadopoulos, Dimitrios C. ;

Kapsalaki, Eftychia Z. ;

Fountas, Kostas N. .

NEUROSURGICAL FOCUS, 2010, 29 (05) :1-5

[7] Pediatric concentrations of S100B protein in blood: Age- and sex-related changes [J].

Gazzolo, D ;

Michetti, F ;

Bruschettini, M ;

Marchese, N ;

Lituania, M ;

Mangraviti, S ;

Pedrazzi, E ;

Bruschettini, P .

CLINICAL CHEMISTRY, 2003, 49 (06) :967-970

[8] Minor head injury in children [J].

Klig, Jean E. ;

Kaplan, Carl P. .

CURRENT OPINION IN PEDIATRICS, 2010, 22 (03) :257-261

[9] Growth charts from birth to 6 years: weight, height and cranial circumference growth according to sex. [J].

Remontet, L ;

Mamelle, N ;

Locard, E ;

Lehingue, Y .

ARCHIVES DE PEDIATRIE, 1999, 6 (05) :520-529

[10] Clinical applications of biomarkers in pediatric traumatic brain injury [J].

Sandler, Simon J. I. ;

Figaji, Anthony A. ;

Adelson, P. David .

CHILDS NERVOUS SYSTEM, 2010, 26 (02) :205-213

← 1 2 →