Dendrite development regulated by CREST, a calcium-regulated transcriptional activator

被引：216

作者：

Aizawa, H ^{[1
]}

Hu, SC ^{[1
]}

Bobb, K ^{[1
]}

Balakrishnan, K ^{[1
]}

Ince, G ^{[1
]}

Gurevich, I ^{[1
]}

Cowan, M ^{[1
]}

Ghosh, A ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA

来源：

SCIENCE | 2004年 / 303卷 / 5655期

关键词：

D O I：

10.1126/science.1089845

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The lasting effects of neuronal activity on brain development involve calcium-dependent gene expression. Using a strategy called transactivator trap, we cloned a calcium-responsive transactivator called CREST (for calcium-responsive transactivator). CREST is a SYT-related nuclear protein that interacts with adenosine 3',5'-monophosphate (cAMP) response element binding protein (CREB)-binding protein (CBP) and is expressed in the developing brain. Mice that have a targeted disruption of the crest gene are viable but display defects in cortical and hippocampal dendrite development. Cortical neurons from crest mutant mice are compromised in calcium-dependent dendritic growth. Thus, calcium activation of CREST-mediated transcription helps regulate neuronal morphogenesis.

引用

页码：197 / 202

页数：6

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