Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology

被引:2543
作者
Silverberg, Mark S. [1 ]
Satsangi, Jack [2 ]
Ahmad, Tariq [3 ]
Arnott, Ian D. R. [2 ]
Bernstein, Charles N. [4 ]
Brant, Steven R. [5 ,6 ]
Caprilli, Renzo [7 ]
Colombel, Jean-Frederic [8 ]
Gasche, Christoph [9 ]
Geboes, Karel [10 ]
Jewell, Derek P. [11 ]
Karban, Amir [12 ]
Loftus, Edward V., Jr. [13 ]
Pena, A. Salvador [14 ]
Riddell, Robert H. [15 ]
Sachar, David B. [16 ]
Schreiber, Stefan [17 ]
Steinhart, A. Hillary [1 ]
Targan, Stephan R. [18 ,19 ]
Vermeire, Severine [20 ]
Warren, Bryan F. [21 ]
机构
[1] Univ Toronto, Mt Sinai Hosp, IBD Ctr, Dept Med, Toronto, ON M5G 1X5, Canada
[2] Univ Edinburgh, Western Gen Hosp, Dept Gastroenterol, Edinburgh, Midlothian, Scotland
[3] Univ Oxford, Radcliffe Infirm, Gibson Labs, Gastroenterol Unit, Oxford OX2 6HE, England
[4] Univ Manitoba, Dept Med, Gastroenterol Sect, IBD Clin & Res Ctr, Winnipeg, MB, Canada
[5] Johns Hopkins Univ, Sch Med, Dept Med, Harvey M & Lyn P Meyerhoff Inflammatory Bowel Dis, Baltimore, MD 21205 USA
[6] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA
[7] Univ Roma La Sapienza, Dept Clin Sci, Rome, Italy
[8] CH&U Lille, Hop Huriez, Dept Hepatogastroenterol & Registre EPIMAD, Lille, France
[9] Med Univ Vienna, Div Gastroenterol & Hepatol, Vienna, Austria
[10] Univ Hosp, Dept Pathol, Louvain, Belgium
[11] Univ Oxford, Dept Gastroenterol, Oxford, England
[12] Technion Israel Inst Technol, Bruce Rappaport Fac Med, Rambam Med Ctr, Dept Gastroenterol, IL-31096 Haifa, Israel
[13] Mayo Clin, Coll Med, Div Gastroenterol & Hepatol, Rochester, MN USA
[14] Vrije Univ Amsterdam, Med Ctr, Dept Pathol, Amsterdam, Netherlands
[15] Univ Toronto, Mt Sinai Hosp, Dept Pathol, Toronto, ON M5G 1X5, Canada
[16] Mt Sinai Sch Med, New York, NY USA
[17] Univ Kiel, Inst Clin Mol Biol, Kiel, Germany
[18] Univ Calif Los Angeles, Sch Med, Cedars Sinai Div Gastroenterol, Ctr Inflammatory Bowel Dis, Los Angeles, CA USA
[19] Univ Calif Los Angeles, Sch Med, Inst Immunobiol, Los Angeles, CA USA
[20] Univ Hosp Gasthuisberg, Div Gastroenterol, B-3000 Louvain, Belgium
[21] Univ Oxford, John Radcliffe Hosp, Dept Cellular Pathol, Oxford OX3 9DU, England
来源
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 2005年 / 19卷
关键词
Anti-Saccharomyces cerevisiae antibodies; Crohn's disease; HLA complex; Indeterminate colitis; NOD2/CARD15; Ulcerative colitis;
D O I
10.1155/2005/269076
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The discovery of a series of genetic and serological markers associated with disease susceptibility and phenotype in inflammatory bowel disease has led to the prospect of an integrated classification system involving clinical, serological and genetic parameters. The Working Party has reviewed current clinical classification systems in Crohn's disease, ulcerative colitis and indeterminate colitis, and provided recommendations for clinical classification in practice. Progress with respect to integrating serological and genetic markets has been examined in detail, and the implications are discussed. While an integrated system is not proposed for clinical use at present, the introduction of a widely acceptable clinical subclassification is strongly advocated, which Would allow detailed correlations among serotype, genotype and clinical phenotype to be examined and confirmed in independent cohorts of patients and, thereby, provide a vital foundation for future work.
引用
收藏
页码:5A / 36A
页数:32
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