Optimization of feeding profile for baker's yeast production by dynamic programming

An optimal substrate feeding for an industrial scale fed-batch fermenter is determined through iterative dynamic programming in order to maximize the cell-mass production and to minimize the ethanol formation. An experimentally validated rigorous dynamic model comprises constraints in the optimization problem. A new objective function is proposed to accommodate the competing requirements of maximum yeast production and minimum ethanol formation. The objective function is maximized with iterative dynamic programming with respect to the sugar feed rate. Results prove the effectiveness of dynamic programming for solving such high-dimensional and nonlinear optimization problems, and the resulting optimal policy indicates that considerable increase in yeast production in fed-batch fermenters can be achieved while minimizing the undesired by-product, ethanol.