Single nucleotide polymorphisms in the peroxisome proliferator-activated receptor δ gene are associated with skeletal muscle glucose uptake

被引：46

作者：

Vänttinen, M

Nuutila, P

Kuulasmaa, T

Pihlajamäki, J

Hällsten, K

Virtanen, KA

Lautamäki, R

Peltoniemi, P

Takala, T

Viljanen, APM

Knuuti, J

Laakso, M ^{[1
]}

机构：

[1] Univ Kuopio, Dept Med, SF-70210 Kuopio, Finland

[2] Univ Turku, Positron Emiss Tomog Ctr, Turku, Finland

[3] Univ Turku, Dept Med, Turku, Finland

来源：

DIABETES | 2005年 / 54卷 / 12期

关键词：

D O I：

10.2337/diabetes.54.12.3587

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The peroxisome proliferator-activated receptors (PPARs) belong to a superfamily of nuclear receptors. It includes PPAR-delta, a key regulator of fatty acid oxidation and energy uncoupling, universally expressed in different tissues. The PPAR-delta gene (PPARD) maps to 6p21.2-p21.1 and has 11 exons and spans 35 kbp. We investigated the effects of single nucleotide polymorphisms (SNPs) of PPARD on whole-body, skeletal muscle, and subcutaneous adipose tissue glucose uptake in 129 healthy individuals using the hyperinsulinemic-euglycemic clamp technique combined with fluorine-18-labeled fluorodeoxyglucose ([F-18]FDG) and positron emission tomography (PET). Three of six SNPs of PPARD and their haplogenotypes were significantly associated with whole-body insulin sensitivity. [F-18]FDG-PET scanning indicated that SNPs of PPARD primarily affected insulin sensitivity by modifying glucose uptake in skeletal muscle but not in adipose tissue. Our results give evidence that SNPs of PPARD regulate insulin sensitivity particularly in skeletal muscle.

引用

页码：3587 / 3591

页数：5

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