Bovine BMP osteoinductive potential enhanced by functionalized dextran-derived hydrogels

被引：45

作者：

Maire, M

Chaubet, F

Mary, P

Blanchat, C

Meunier, A

Logeart-Avramoglou, D

机构：

[1] Univ Paris 07, Fac Med Lariboisiere St Louis, Fac Med, SPI,CNRS,Lab Rech Orthoped,UMR 7052, F-75010 Paris, France

[2] Univ Paris 13, Bichat Hosp, INSERM, ERIT M,Lab Bioingn Polymeres Cardiovasc, F-75877 Paris, France

[3] Univ Paris 07, F-75877 Paris, France

来源：

BIOMATERIALS | 2005年 / 26卷 / 24期

关键词：

hydrogel; functionalized dextran; BMP delivery system; osteoinduction; ectopic site;

D O I：

10.1016/j.biomaterials.2005.01.020

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

This study evaluated functionalized dextran-derived hydrogels as BMP carriers using both in vitro and in vivo models. In vitro release kinetics indicated that dextran-derived hydrogels could retain rhBMP-2 growth factor in a variable manner depending on their functionalization ratio. The potential of these hydrogels when combined with extracted bovine BMP to enhance the bone formation was evaluated in a rat ectopic model. The largest osteoinduction was found when using hydrogels exhibiting the highest growth factor retention capacity. In addition, some implanted hydrogels demonstrated a capacity to induce an in-vivo calcification certainly related to their chemical composition. These properties make these materials interesting osteoconductive BMP carriers, allowing to decrease the amount of implanted factor required for bone regeneration. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：5085 / 5092

页数：8

共 25 条

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