Pharmacokinetic, pharmacodynamic and formulations aspects of Naringenin: An update

被引：194

作者：

Joshi, Ruthvika ^{[1
]}

Kulkarni, Yogesh A. ^{[1
]}

Wairkar, Sarika ^{[1
]}

机构：

[1] SVKMs NMIMS, Shobhaben Pratapbhai Patel Sch Pharm & Technol Ma, VL Mehta Rd, Bombay 400056, Maharashtra, India

来源：

LIFE SCIENCES | 2018年 / 215卷

关键词：

Bioavailability; Formulations; Naringenin; Pharmacological activities; Pharmacokinetics; LIPOSOMAL NANOFORMULATION PREPARATION; NITRIC-OXIDE SYNTHASE; BREAST-CANCER CELLS; FLAVONOID NARINGENIN; CITRUS FLAVONOIDS; OXIDATIVE STRESS; IN-VITRO; CYCLOOXYGENASE-2; EXPRESSION; FLAVANONE NARINGENIN; INFLAMMATORY PAIN;

D O I：

10.1016/j.lfs.2018.10.066

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Phenolic compounds constitute one of the important classes of secondary metabolites in the plants. Flavonoids are primary phenolic compounds found in natural drugs. Naringenin is a flavanone, aglycone of Naringin, predominantly found in citrus fruits with various pharmacological activities. Large number of scientific papers has been published on Naringenin describing its structure, physicochemical properties and its therapeutic use in different diseases. This review provides highlights of Naringenin with respect to its distribution, pharmacokinetic and its use in conditions like oxidative stress, inflammation, cancer, diabetes, cardiovascular diseases and neurological disorders. Furthermore, the review also focuses on molecular level mechanisms of Naringenin for its therapeutic effect. Various attempts have been made to formulate advanced dosage forms to address issue of solubility of Naringenin. Systematic review of data published on formulation aspects of Naringenin has also been presented in the article.

引用

页码：43 / 56

页数：14

共 110 条

[1]

The differential tissue distribution of the citrus flavanone naringenin following gastric instillation [J].