Timeline - RAS oncogenes: the first 30 years

被引：1394

作者：

Malumbres, M ^{[1
]}

Barbacid, M ^{[1
]}

机构：

[1] CNIO, Mol Oncol Programme, Madrid 28029, Spain

来源：

NATURE REVIEWS CANCER | 2003年 / 3卷 / 06期

关键词：

D O I：

10.1038/nrc1097

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

From the pioneering work with acute transforming retroviruses to the current post-genomic era, RAS genes have always been at the leading edge of signal transduction and molecular oncology. Yet, a complete understanding of RAS function and dysfunction - mainly in human cancer - is still to come. The knowledge that has accumulated since their discovery 30 years ago has, however, been remarkable, and should pave the way for not only solving the outstanding issues regarding RAS biology, but also for developing efficacious drugs that could have a significant impact on cancer treatment.

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页码：459 / 465

页数：7

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