Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

被引：1056

作者：

Wu, Davina ^{[1
]}

Molofsky, Ari B. ^{[2
]}

Liang, Hong-Erh ^{[1
]}

Ricardo-Gonzalez, Roberto R. ^{[3
]}

Jouihan, Hani A. ^{[3
]}

Bando, Jennifer K. ^{[1
]}

Chawla, Ajay ^{[4
,5
,6
]}

Locksley, Richard M. ^{[1
,7
,8
]}

机构：

[1] Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA

[3] Stanford Univ, Sch Med, Dept Med, Div Endocrinol Metab & Gerontol, Stanford, CA 94305 USA

[4] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94107 USA

[5] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94107 USA

[6] Univ Calif San Francisco, Dept Med, San Francisco, CA 94107 USA

[7] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[8] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

来源：

SCIENCE | 2011年 / 332卷 / 6026期

关键词：

T-CELLS; IN-VIVO; INSULIN-RESISTANCE; TISSUE; INFLAMMATION; OBESITY; POLARIZATION; EXPRESSION; CYTOKINES; DISEASE;

D O I：

10.1126/science.1201475

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Eosinophils are associated with helminth immunity and allergy, often in conjunction with alternatively activated macrophages (AAMs). Adipose tissue AAMs are necessary to maintain glucose homeostasis and are induced by the cytokine interleukin-4 (IL-4). Here, we show that eosinophils are the major IL-4-expressing cells in white adipose tissues of mice, and, in their absence, AAMs are greatly attenuated. Eosinophils migrate into adipose tissue by an integrin-dependent process and reconstitute AAMs through an IL-4- or IL-13-dependent process. Mice fed a high-fat diet develop increased body fat, impaired glucose tolerance, and insulin resistance in the absence of eosinophils, and helminth-induced adipose tissue eosinophilia enhances glucose tolerance. Our results suggest that eosinophils play an unexpected role in metabolic homeostasis through maintenance of adipose AAMs.

引用

页码：243 / 247

页数：5

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