Effects of oligoDNA template length and sequence on binary self-assembly of a nucleotide bolaamphiphile

被引：14

作者：

Iwaura, Rika

Kikkawa, Yoshihiro

Ohnishi-Kameyama, Mayumi

Shimizu, Toshimi

机构：

[1] Natl Food Res Inst, Natl Agr & Food Res Org, Tsukuba, Ibaraki 305, Japan

[2] Natl Inst Adv Ind Sci & Technol, Nanoarchitect Res Ctr, Tsukuba, Ibaraki 305, Japan

[3] Japan Sci & Technol Agcy, SORST, Tsukuba, Ibaraki 305, Japan

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2007年 / 5卷 / 21期

关键词：

D O I：

10.1039/b711687j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Templated self-assembly of nucleotide bolaamphiphile 1 ( in which a 3'-phosphorylated thymidine moiety is connected to each end of a long oligomethylene chain) with a 10-, 20-, 30-, or 40-meric single-stranded oligoadenylic acid ( 2, 3, 4, or 5) led to the formation of right-handed helical nanofibers in 0.1 x Tris/EDTA (TE) buffer solutions. The helical pitch increased as the length of the oligoadenylic acid template increased. DNA composed of oligoadenylic and oligocytidylic acid sequences ( 6, 7, and 8) also acted as templates to induce the formation of helical nanofiber structures. The diameter of the nanofibers remained constant (6-6.6 nm) irrespective of the template used. The binary self-assembly of 1 with 4 also produced higher-order, double-stranded nanofibers.

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页码：3450 / 3455

页数：6

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