Fate mapping of IL-17-producing T cells in inflammatory responses

被引：924

作者：

Hirota, Keiji ^{[1
]}

Duarte, Joao H. ^{[1
]}

Veldhoen, Marc ^{[1
]}

Hornsby, Eve ^{[1
]}

Li, Ying ^{[1
]}

Cua, Daniel J. ^{[2
]}

Ahlfors, Helena ^{[1
]}

Wilhelm, Christoph ^{[1
]}

Tolaini, Mauro ^{[1
]}

Menzel, Ursula ^{[1
]}

Garefalaki, Anna ^{[1
]}

Potocnik, Alexandre J. ^{[1
]}

Stockinger, Brigitta ^{[1
]}

机构：

[1] Natl Inst Med Res, MRC, Div Mol Immunol, London NW7 1AA, England

[2] Merck Res Labs, Palo Alto, CA USA

来源：

NATURE IMMUNOLOGY | 2011年 / 12卷 / 03期

基金：

欧洲研究理事会; 英国医学研究理事会;

关键词：

CENTRAL-NERVOUS-SYSTEM; TH17; CELLS; TGF-BETA; HELPER TYPE-1; DIFFERENTIATION; PLASTICITY; LINEAGE; RECEPTOR; AUTOIMMUNITY; EXPRESSION;

D O I：

10.1038/ni.1993

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Here we describe a reporter mouse strain designed to map the fate of cells that have activated interleukin 17A (IL-17A). We found that IL-17-producing helper T cells (T(H)17 cells) had distinct plasticity in different inflammatory settings. Chronic inflammatory conditions in experimental autoimmune encephalomyelitis (EAE) caused a switch to alternative cytokines in T(H)17 cells, whereas acute cutaneous infection with Candida albicans did not result in the deviation of T(H)17 cells to the production of alternative cytokines, although IL-17A production was shut off in the course of the infection. During the development of EAE, interferon-gamma (IFN-gamma) and other proinflammatory cytokines in the spinal cord were produced almost exclusively by cells that had produced IL-17 before their conversion by IL-23 ('ex-T(H)17 cells'). Thus, this model allows the actual functional fate of effector T cells to be related to T(H)17 developmental origin regardless of IL-17 expression.

引用

页码：255 / U95

页数：10

共 52 条

[1] Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells [J].

Ahern, Philip P. ;

Schiering, Chris ;

Buonocore, Sofia ;

McGeachy, Mandy J. ;

Cua, Dan J. ;

Maloy, Kevin J. ;

Powrie, Fiona .

IMMUNITY, 2010, 33 (02) :279-288

[2] Phenotypic and functional features of human Th17 cells [J].

Annunziato, Francesco ;

Cosmi, Lorenzo ;

Santarlasci, Veronica ;

Maggi, Laura ;

Liotta, Francesco ;

Mazzinghi, Benedetta ;

Parente, Eliana ;

Fili, Lucia ;

Ferri, Simona ;

Frosali, Francesca ;

Giudici, Francesco ;

Romagnani, Paola ;

Parronchi, Paola ;

Tonelli, Francesco ;

Maggi, Enrico ;

Romagnani, Sergio .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (08) :1849-1861

[3] T helper type 1 and 17 cells determine efficacy of interferon-β in multiple sclerosis and experimental encephalomyelitis [J].

Axtell, Robert C. ;

de Jong, Brigit A. ;

Boniface, Katia ;

van der Voort, Laura F. ;

Bhat, Roopa ;

De Sarno, Patrizia ;

Naves, Rodrigo ;

Han, May ;

Zhong, Franklin ;

Castellanos, Jim G. ;

Mair, Robert ;

Christakos, Athena ;

Kolkowitz, Ilan ;

Katz, Liat ;

Killestein, Joep ;

Polman, Chris H. ;

Malefyt, Rene de Waal ;

Steinman, Lawrence ;

Raman, Chander .

NATURE MEDICINE, 2010, 16 (04) :406-U21

[4] Central nervous system plasmacytoid dendritic cells regulate the severity of relapsing experimental autoimmune encephalomyelitis [J].

Bailey-Bucktrout, Samantha L. ;

Caulkins, Sarah C. ;

Goings, Gwendolyn ;

Fischer, Jens A. A. ;

Dzionek, Andrzej ;

Miller, Stephen D. .

JOURNAL OF IMMUNOLOGY, 2008, 180 (10) :6457-6461

[5] Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice [J].

Bending, David ;

De La Pena, Hugo ;

Veldhoen, Marc ;

Phillips, Jenny M. ;

Uyttenhove, Catherine ;

Stockinger, Brigitta ;

Cooke, Anne .

JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (03) :565-572

[6] Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis [J].

Bettelli, E ;

Pagany, M ;

Weiner, HL ;

Linington, C ;

Sobel, RA ;

Kuchroo, AK .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (09) :1073-1081

[7] IL-12- and IL-23-induced T helper cell subsets: birds of the same feather flock together [J].

Bettelli, E ;

Kuchroo, VK .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (02) :169-171

[8] Human Th17 Cells Comprise Heterogeneous Subsets Including IFN-γ-Producing Cells with Distinct Properties from the Th1 Lineage [J].

Boniface, Katia ;

Blumenschein, Wendy M. ;

Brovont-Porth, Katherine ;

McGeachy, Mandy J. ;

Basham, Beth ;

Desai, Bela ;

Pierce, Robert ;

McClanahan, Terrill K. ;

Sadekova, Svetlana ;

Malefyt, Rene de Waal .

JOURNAL OF IMMUNOLOGY, 2010, 185 (01) :679-687

[9] IL-17F: Regulation, signaling and function in inflammation [J].

Chang, Seon Hee ;

Dong, Chen .

CYTOKINE, 2009, 46 (01) :7-11

[10] Cutting Edge: An IL-17F-CreEYFP Reporter Mouse Allows Fate Mapping of Th17 Cells [J].

Croxford, Andrew L. ;

Kurschus, Florian C. ;

Waisman, Ari .

JOURNAL OF IMMUNOLOGY, 2009, 182 (03) :1237-1241

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