IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation

被引：1083

作者：

Lodolce, JP

Boone, DL

Chai, S

Swain, RE

Dassopoulos, T

Trettin, S

Ma, A

机构：

[1] Univ Chicago, Dept Med, Comm Immunol, Chicago, IL 60637 USA

[2] Univ Chicago, Dept Med, Comm Canc Biol, Chicago, IL 60637 USA

来源：

IMMUNITY | 1998年 / 9卷 / 05期

关键词：

D O I：

10.1016/S1074-7613(00)80664-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The IL-15 receptor alpha subunit (IL-15R alpha) mediates high-affinity binding of IL-15, a pleiotropic cytokine implicated in the development of innate immune cells. We have generated IL-15R alpha null (IL-15R alpha(-/-)) mice to understand the role of IL-15R alpha in immune development and function. IL-15R alpha(-/-) mice are markedly lymphopenic despite grossly normal T and B lymphocyte development. This lymphopenia is due to decreased proliferation and decreased homing of IL-15R alpha(-/-) lymphocytes to peripheral lymph nodes. These mice are also deficient in natural killer cells, natural killer T cells, CD8(+) T lymphocytes, and TCR gamma delta intraepithelial lymphocytes. In addition, memory phenotype CD8(+) T cells are selectively reduced in number. Thus, IL-15R alpha has pleiotropic roles in immune development and function, including the positive maintenance of lymphocyte homeostasis.

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页码：669 / 676

页数：8

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