Antibacterial vaccine design using genomics and proteomics

被引：77

作者：

Grandi, G ^{[1
]}

机构：

[1] Chiron SpA, Dept Biol Mol, I-53100 Siena, Italy

来源：

TRENDS IN BIOTECHNOLOGY | 2001年 / 19卷 / 05期

关键词：

D O I：

10.1016/S0167-7799(01)01600-6

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

After 200 years of practice, vaccinology has proved to be very effective in preventing infectious diseases. However, several human and animal pathogens exist for which vaccines have not yet been discovered. As for other fields of medical sciences, it is expected that vaccinology will greatly benefit from the emerging genomics technologies such as bioinformatics, proteomics and DNA microarrays, In this article the potential of these technologies applied to bacterial pathogens is analyzed, taking into account the few existing examples of their application in vaccine discovery.

引用

页码：181 / 188

页数：8

共 52 条

[1] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].