Atrium and paroxetine-related severe hepatitis

被引：13

作者：

Cadranel, JF

Di Martino, V

Cazier, A

Pras, V

Bachmeyer, C

Olympio, P

Gonzenbach, A

Mofredj, A

Coutarel, P

Devergie, B

Biour, M

机构：

[1] Ctr Hosp Laennec, Unite Hepatol, F-60109 Creil, France

[2] Ctr Hosp Laennec, Serv Anatomopathol, F-60109 Creil, France

[3] Ctr Hosp Laennec, Serv Med Interne, F-60109 Creil, France

[4] Hop St Antoine, Ctr Reg Pharmacovigilance, F-75571 Paris, France

来源：

JOURNAL OF CLINICAL GASTROENTEROLOGY | 1999年 / 28卷 / 01期

关键词：

atrium; paroxetine; hepatotoxicity; severe hepatitis; microsomes;

D O I：

10.1097/00004836-199901000-00014

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Two cases of severe hepatitis in young women using Atrium and paroxetine are presented. Both patients presented jaundice, marked increase in aminotransferases activities, and pronounced prolongation in prothrombin time. In both cases, liver biopsy specimen examination revealed lesions compatible with drug-related injury. Other causes of hepatic injury were reasonably ruled out by complete careful screening. Outcome was marked by rapid complete recovery in one case and by slow recovery in the other. We suggest that simultaneous treatment with Atrium and paroxetine could increase each of these drugs' hepatotoxicity.

引用

页码：52 / 55

页数：4

共 21 条

[1]

Benbow SJ, 1997, BRIT MED J, V314, P1387

[2]

BINDER D, 1993, SCHWEIZ MED WOCH S50, V123, P117

[3]

Biour M, 1996, GASTROEN CLIN BIOL, V20, P744

[4]

BOBICHON R, 1993, GASTROEN CLIN BIOL, V17, P406

[5]

BROCHERIOU I, 1993, GASTROEN CLIN BIOL, V17, P305

[6]

CADRANEL JF, 1992, EUR J GASTROEN HEPAT, V4, P943

[7]

CASTIELLA A, 1994, AM J GASTROENTEROL, V89, P458

[8]

CAYLA JM, 1995, PRESSE MED, V24, P1665

[9]

DANAN G, 1990, J HEPATOL, V11, P272

[10]

Friedenberg FK, 1996, AM J PSYCHIAT, V153, P580

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