The absolute configuration of gambierol, a toxic marine polyether from the dinoflagellate, Gambierdiscus toxicus

被引：85

作者：

Morohashi, A ^{[1
]}

Satake, M ^{[1
]}

Yasumoto, T ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Agr Sci, Dept Appl Bioorgan Chem, Aoba Ku, Sendai, Miyagi 9818555, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 01期

关键词：

polyether; stereochemistry; NMR;

D O I：

10.1016/S0040-4039(98)80029-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The axial C6-OH group in gambierol isolated from the dinoflagellate, Gambierdiscus toxicus, was inverted to equatorial disposition and esterified with (S)- and (R)-MTPA. NMR analysis of these esters established S configuration at C6, thus allowing determination of the absolute configuration of the whole molecule. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：97 / 100

页数：4

共 12 条

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