Fibrinogen γ′ in ischemic stroke -: A case-control study

被引：61

作者：

Cheung, Elim Y. L. ^{[1
]}

de Willige, Shirley Uitte ^{[3
]}

Vos, Hans L. ^{[3
]}

Leebeek, Frank W. G. ^{[1
]}

Dippel, Diederik W. J. ^{[2
]}

Bertina, Rogier M. ^{[3
]}

de Maat, Moniek P. M. ^{[1
]}

机构：

[1] Erasmus Univ, Med Ctr, Dept Hematol, NL-3000 CA Rotterdam, Netherlands

[2] Erasmus Univ, Med Ctr, Dept Neurol, NL-3000 CA Rotterdam, Netherlands

[3] Leiden Univ, Med Ctr, Dept Hematol, Haemostasis & Thrombosis Res Ctr, Leiden, Netherlands

来源：

STROKE | 2008年 / 39卷 / 03期

关键词：

FGG haplotypes; fibrinogen gamma '/total fibrinogen ratios; ischemic stroke;

D O I：

10.1161/STROKEAHA.107.495499

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose - To determine the contribution of fibrinogen gamma ' levels and FGG haplotypes to ischemic stroke. Methods - Associations between fibrinogen gamma ' levels, fibrinogen gamma '/total fibrinogen ratio, and FGG haplotypes with the risk of ischemic stroke were determined in 124 cases and 125 controls. Results - Fibrinogen gamma '/total fibrinogen ratio was higher in patients than in controls during the acute phase of the stroke and lower in the convalescent phase 3 months after the stroke. FGG haplotype 3 (H3) was associated with a reduced risk of ischemic stroke (odds ratio 0.60; 95% CI, 0.38 to 0.94), but not with the fibrinogen gamma '/total fibrinogen ratio. In contrast, FGG-H2 was associated with a decreased fibrinogen gamma '/total fibrinogen ratio, but not with risk of stroke. Conclusions - Fibrinogen gamma '/total fibrinogen ratio is associated with ischemic stroke, especially in the acute phase of the disease. In addition, FGG-H3 haplotype appears to be protective against ischemic stroke.

引用

页码：1033 / 1035

页数：3

共 8 条

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