Late-onset myasthenia gravis - A changing scene

被引:96
作者
Aarli, JA [1 ]
机构
[1] Univ Bergen, Dept Neurol, Bergen, Norway
关键词
D O I
10.1001/archneur.56.1.25
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The prevalence of myasthenia gravis (MG) among middle-aged and older patients has increased. Patients with early-onset MG live longer than before, but there is also an increase in late-onset MG (onset of the disease after the age of 50 years in patients with no clinical or paraclinical evidence of a thymoma). Epidemiological data support using the age of 50 years to separate early- and late-onset MG. The main immunological difference between early- and late-onset MG is the presence of antibodies to muscle titin, which are detected in approximately 50% of patients with late-onset MG. Treatment of late-onset MG has to be tailored both to the age of the patient and to the immunological findings of that particular form of MG.
引用
收藏
页码:25 / 27
页数:3
相关论文
共 31 条
[1]   Late onset myasthenia gravis [J].
Aarli, JA .
EUROPEAN JOURNAL OF NEUROLOGY, 1997, 4 (03) :203-209
[2]  
AARLI JA, 1990, CLIN EXP IMMUNOL, V82, P284
[3]  
AIRD RB, 1955, CN, V3, P1498
[4]  
[Anonymous], AGEING EUROPE
[5]   Myasthenia gravis: Diagnosis and follow-up of 100 consecutive patients [J].
Beekman, R ;
Kuks, JBM ;
Oosterhuis, HJGH .
JOURNAL OF NEUROLOGY, 1997, 244 (02) :112-118
[6]  
Campbell H.B.E, 1900, BRAIN, V23, P277, DOI [10.1093/brain/23.2.277, DOI 10.1093/BRAIN/23.2.277]
[7]   Mortality and survival in myasthenia gravis: a Danish population based study [J].
Christensen, PB ;
Jensen, TS ;
Tsiropoulos, I ;
Sorensen, T ;
Kjaer, M ;
Hojer-Pedersen, E ;
Rasmussen, MJK ;
Lehfeldt, E .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1998, 64 (01) :78-83
[8]   INCIDENCE AND PREVALENCE OF MYASTHENIA-GRAVIS IN WESTERN DENMARK - 1975 TO 1989 [J].
CHRISTENSEN, PB ;
JENSEN, TS ;
TSIROPOULOS, I ;
SORENSEN, T ;
KJAER, M ;
HOJERPEDERSEN, E ;
RASMUSSEN, MJK ;
LEHFELDT, E ;
OLIVARIUS, BD .
NEUROLOGY, 1993, 43 (09) :1779-1783
[9]   CLINICAL, PATHOLOGICAL, HLA-ANTIGEN AND IMMUNOLOGICAL EVIDENCE FOR DISEASE HETEROGENEITY IN MYASTHENIA-GRAVIS [J].
COMPSTON, DAS ;
VINCENT, A ;
NEWSOMDAVIS, J ;
BATCHELOR, JR .
BRAIN, 1980, 103 (SEP) :579-601
[10]   THE RELATIONSHIP OF AGE TO OUTCOME IN MYASTHENIA-GRAVIS [J].
DONALDSON, DH ;
ANSHER, M ;
HORAN, S ;
RUTHERFORD, RB ;
RINGEL, SP .
NEUROLOGY, 1990, 40 (05) :786-790