α1-Antitrypsin deficiency•2:: Genetic aspects of α1-antitrypsin deficiency:: phenotypes and genetic modifiers of emphysema risk

被引：166

作者：

DeMeo, DL

Silverman, EK

机构：

[1] Brigham & Womens Hosp, Channing Lab, Boston, MA 02446 USA

[2] Brigham & Womens Hosp, Dept Med, Div Pulm & Crit Care Med, Boston, MA 02446 USA

来源：

THORAX | 2004年 / 59卷 / 03期

关键词：

D O I：

10.1136/thx.2003.006502

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The genetic aspects of AAT deficiency and the variable manifestations of lung disease in PI Z individuals are reviewed. The role of modifying genetic factors which may interact with environmental factors (such as cigarette smoking) is discussed, and directions for future research are presented.

引用

页码：259 / 264

页数：6

共 63 条

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[2]

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[3]

BLACK LF, 1978, AM REV RESPIR DIS, V117, P421

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