Lactic acid polymers as biodegradable carriers of fluoroquinolones: An in vitro study

被引：42

作者：

Kanellakopoulou, K

Kolia, M

Anastassiadis, A

Korakis, T

Giamarellos-Bourboulis, EJ

Andreopoulos, A

Dounis, E

Giamarellou, H ^{[1
]}

机构：

[1] Sismanogl Gen Hosp, Athens Med Sch, Dept Internal Med 4, Athens 15126, Greece

[2] Athend Med Sch, Dept Propedeut Med 1, Athens, Greece

[3] Laiko Gen Hosp, Dept Orthopaed, Athens, Greece

[4] Athens Polytech Sch, Dept Chem Engn, Athens, Greece

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 03期

关键词：

D O I：

10.1128/AAC.43.3.714

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A biodegradable polymer of DL-dilactide that facilitates release of ciprofloxacin or pefloxacin at levels exceeding MICs for the causative microorganisms of chronic osteomyelitis is described. Duration and peak of release were found to depend on the molecular weight of the polymer. Its characteristics make it promising for treating chronic bone infections.

引用

页码：714 / 716

页数：3

共 16 条

[1] In vitro release of new quinolones from biodegradable systems: A comparative study [J].