Improved protocol for asymmetric, intramolecular heteroatom Michael addition using organocatalysis: Enantioselective syntheses of homoproline, pelletierine, and homopipecolic acid

被引：89

作者：

Carlson, Erik C. ^{[1
]}

Rathbone, Lauren K. ^{[1
]}

Yang, Hua ^{[1
]}

Collett, Nathan D. ^{[1
]}

Carter, Rich G. ^{[1
]}

机构：

[1] Oregon State Univ, Dept Chem, Corvallis, OR 97331 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 73卷 / 13期

关键词：

D O I：

10.1021/jo800749t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An improved protocol for the construction of enantioenriched pyrrolidine, indoline, and piperidine rings using an organo-catalyzed, intramolecular heteroatom Michael addition is described. Application to the enantioselective synthesis of homoproline, homopipecolic acid, and pelletierine has been accomplished.

引用

页码：5155 / 5158

页数：4

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