Skeletal resistance to PTH as a basic abnormality underlying uremic bone diseases

被引:35
作者
Fukagawa, M
Kazama, JJ
Shigematsu, T
机构
[1] Kobe Univ, Sch Med, Div Nephrol, Chuo Ku, Kobe, Hyogo 6500017, Japan
[2] Niigata Univ, Sch Med, Niigata, Japan
[3] Jikei Med Sch, Tokyo, Japan
关键词
parathyroid hormone (PTH); adynamic bone; osteoclastogenesis inhibitory factor (OCIF); osteoprotegerin;
D O I
10.1053/ajkd.2001.27426
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Skeletal resistance to parathyroid hormone (PTH) was suggested initially as a mechanism of PTH hypersecretion in uremia. Because of the effective suppression of PTH by recently developed therapeutic modalities, this background abnormality has been uncovered and currently recognized as relative hypoparathyroidism In terms of its relation to bone turnover. Thus, PTH levels two to three times greater than normal are usually required to keep bone turnover normal in uremia. Recent studies suggested that PTH activity may be overestimated using the conventional intact PTH assay. In addition, several steps to osteoclastogenesis are suspected to be disturbed In uremia. Additional studies at cellular and molecular levels are needed to establish preventive and therapeutic modalities for this abnormality. (C) 2001 by the National Kidney Foundation, Inc.
引用
收藏
页码:S152 / S155
页数:4
相关论文
共 20 条
[1]   Cell biology of parathyroid hyperplasia in uremia [J].
Fukagawa, M .
AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 1999, 317 (06) :377-382
[2]   ROLE OF 1,25-DIHYDROXYVITAMIN D ON THE SKELETAL RESISTANCE TO PARATHYROID-HORMONE [J].
GALCERAN, T ;
MARTIN, KJ ;
MORRISSEY, JJ ;
SLATOPOLSKY, E .
KIDNEY INTERNATIONAL, 1987, 32 (06) :801-807
[3]   APLASTIC OSTEODYSTROPHY WITHOUT ALUMINUM - THE ROLE OF SUPPRESSED PARATHYROID FUNCTION [J].
HERCZ, G ;
PEI, Y ;
GREENWOOD, C ;
MANUEL, A ;
SAIPHOO, C ;
GOODMAN, WG ;
SEGRE, GV ;
FENTON, S ;
SHERRARD, DJ .
KIDNEY INTERNATIONAL, 1993, 44 (04) :860-866
[4]   THE BIOLOGICAL ACTION OF CALCITRIOL IN RENAL-FAILURE [J].
HSU, CH ;
PATEL, SR ;
YOUNG, EW ;
VANHOLDER, R .
KIDNEY INTERNATIONAL, 1994, 46 (03) :605-612
[5]   A novel immunoradiometric assay detects full-length human PTH but not amino-terminally truncated fragments:: Implications for PTH measurements in renal failure [J].
John, MR ;
Goodman, WG ;
Gao, P ;
Cantor, TL ;
Salusky, IB ;
Jüppner, H .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1999, 84 (11) :4287-4290
[6]   EVIDENCE FOR ABNORMAL CALCIUM HOMEOSTASIS IN PATIENTS WITH ADYNAMIC BONE-DISEASE [J].
KURZ, P ;
MONIERFAUGERE, MC ;
BOGNAR, B ;
WERNER, E ;
ROTH, P ;
VLACHOJANNIS, J ;
MALLUCHE, HH .
KIDNEY INTERNATIONAL, 1994, 46 (03) :855-861
[7]  
Lepage R, 1998, CLIN CHEM, V44, P805
[8]   SKELETAL RESISTANCE TO ENDOGENOUS PARATHYROID-HORMONE IN PATIENTS WITH EARLY RENAL-FAILURE - POSSIBLE CAUSE FOR SECONDARY HYPERPARATHYROIDISM [J].
LLACH, F ;
MASSRY, SG ;
SINGER, FR ;
KUROKAWA, K ;
KAYE, JH ;
COBURN, JW .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1975, 41 (02) :339-345
[9]   SKELETAL RESISTANCE TO PARATHYROID-HORMONE IN RENAL-FAILURE - STUDIES IN 105 HUMAN SUBJECTS [J].
MASSRY, SG ;
COBURN, JW ;
LEE, DBN ;
JOWSEY, J ;
KLEEMAN, CR .
ANNALS OF INTERNAL MEDICINE, 1973, 78 (03) :357-364
[10]   PREDICTIVE VALUE OF SERUM PARATHYROID-HORMONE LEVELS FOR BONE TURNOVER IN PATIENTS ON CHRONIC MAINTENANCE DIALYSIS [J].
QI, QL ;
MONIERFAUGERE, MC ;
GENG, ZP ;
MALLUCHE, HH .
AMERICAN JOURNAL OF KIDNEY DISEASES, 1995, 26 (04) :622-631