Integrin tyrosine phosphorylation in platelet signaling

被引：81

作者：

Phillips, DR ^{[1
]}

Prasad, KSS ^{[1
]}

Manganello, J ^{[1
]}

Bao, M ^{[1
]}

Nannizzi-Alaimo, L ^{[1
]}

机构：

[1] COR Therapeut Inc, San Francisco, CA 94080 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2001年 / 13卷 / 05期

关键词：

D O I：

10.1016/S0955-0674(00)00250-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The beta3 integrin cytoplasmic tyrosine (ICY) motif of alpha IIb beta3 becomes tyrosine phosphorylated during platelet aggregation, causing Shc and myosin to interact with the beta -integrin cytoplasmic domain. Platelets from mice lacking beta3 ICY motif tyrosines formed defective aggregates and poorly retracted clots, establishing integrin tyrosine phosphorylation as a key mediator of beta3-integrin signals.

引用

收藏

页码：546 / 554

页数：9

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