Dopamine gates LTP induction in lateral amygdala by suppressing feedforward inhibition

被引：312

作者：

Bissière, S ^{[1
]}

Humeau, Y ^{[1
]}

Lüthi, A ^{[1
]}

机构：

[1] Univ Basel, Bioctr, Dept Pharmacol Neurobiol, CH-4056 Basel, Switzerland

来源：

NATURE NEUROSCIENCE | 2003年 / 6卷 / 06期

关键词：

D O I：

10.1038/nn1058

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Fear conditioning involves the induction of long-term potentiation (LTP) of excitatory synaptic transmission in the lateral amygdala, a brain structure which is tightly controlled by GABAergic inhibition. Here we show that dopamine gates the induction of LTP in the mouse lateral amygdala by suppressing feedforward inhibition from local interneurons. Our findings provide a cellular mechanism for the dopaminergic modulation of fear conditioning and indicate that suppression of feedforward inhibition represents a key mechanism for the induction of associative synaptic plasticity in the lateral amygdala.

引用

页码：587 / 592

页数：6

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