Abundant human β-defensin-1 expression in milk and mammary gland epithelium

被引：79

作者：

Jia, HP

Starner, T

Ackermann, M

Kirby, P

Tack, BF

McCray, PB ^{[1
]}

机构：

[1] Univ Iowa, Coll Med, Dept Pediat, Iowa City, IA 52242 USA

[2] Univ Iowa, Coll Med, Dept Microbiol, Iowa City, IA 52242 USA

[3] Univ Iowa, Coll Med, Dept Pathol, Iowa City, IA 52242 USA

[4] Iowa State Univ, Dept Vet Pathol, Ames, IA USA

来源：

JOURNAL OF PEDIATRICS | 2001年 / 138卷 / 01期

关键词：

D O I：

10.1067/mpd.2001.109375

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Human beta -defensin-1 (HBD-1) was detected in breast milk in concentrations of similar to1 to 10 mug/mL. Breast tissue during lactation showed HBD-1 expression in mammary gland epithelia and within luminal secretions. The peptide demonstrated antimicrobial activity against Escherichia coli. HBD-1 may augment neonatal host defenses through antimicrobial effects or prime the adaptive immune system at mucosal surfaces.

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页码：109 / 112

页数：4

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