Human CD8+ T cells specific for Mycobacterium tuberculosis secreted antigens in tuberculosis patients and healthy BCG-vaccinated controls in The Gambia

被引：68

作者：

Smith, SM

Klein, MR

Malin, AS

Sillah, J

Huygen, K

Andersen, P

McAdam, KPWJ

Dockrell, HM

机构：

[1] Univ London London Sch Hyg & Trop Med, Immunol Unit, London WC1E 7HT, England

[2] MRC Labs, TB Res Programme, Fajara, Gambia

[3] Inst Pasteur, Brussels, Belgium

[4] Statens Serum Inst, Dept TB Immunol, DK-2300 Copenhagen, Denmark

来源：

INFECTION AND IMMUNITY | 2000年 / 68卷 / 12期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/IAI.68.12.7144-7148.2000

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Intracellular flow cytometry analysis of perforin production by CD8(+) T cells showed levels were greatly reduced in tuberculosis (TB) patients compared to healthy controls. Reduced cytotoxic-T-lymphocyte activity was also obtained with CD8(+) T cells from TB patients compared to healthy controls in The Gambia. A change in antigen recognition was noted between the two groups of donors: in addition to recognition of Ag85A and Ag85B, as seen in healthy donors, a prominent ESAT-6 response was found in TB patients.

引用

收藏

页码：7144 / 7148

页数：5

相关论文

共 27 条

[1]

ANDERSEN P, 1995, J IMMUNOL, V154, P3359

[2]

Canaday DH, 1999, J IMMUNOL, V162, P372

[3] The course of Mycobacterium tuberculosis infection in the lungs of mice lacking expression of either perforin- or granzyme-mediated cytolytic mechanisms [J].

Cooper, AM ;

DSouza, C ;

Frank, AA ;

Orme, IM .

INFECTION AND IMMUNITY, 1997, 65 (04) :1317-1320

[4] Characterization of the culture filtrate-specific cytotoxic T lymphocyte response induced by bacillus Calmette-Guerin vaccination in H-2b mice [J].

Denis, O ;

Huygen, K .

INTERNATIONAL IMMUNOLOGY, 1999, 11 (02) :209-216

[5] Induction of cytotoxic T-Cell responses against culture filtrate antigens in Mycobacterium bovis bacillus Calmette-Guerin-infected mice [J].

Denis, O ;

Lozes, E ;

Huygen, K .

INFECTION AND IMMUNITY, 1997, 65 (02) :676-684

[6] Vaccination with plasmid DNA encoding mycobacterial antigen 85A stimulates a CD4+ and CD8+ T-cell epitopic repertoire broader than that stimulated by Mycobacterium tuberculosis H37Rv infection [J].

Denis, O ;

Tanghe, A ;

Palfliet, K ;

Jurion, F ;

van den Berg, TP ;

Vanonckelen, A ;

Ooms, J ;

Saman, E ;

Ulmer, JB ;

Content, J ;

Huygen, K .

INFECTION AND IMMUNITY, 1998, 66 (04) :1527-1533

[7] MYCOBACTERIAL DISEASES [J].

FINE, PEM ;

RODRIGUES, LC .

LANCET, 1990, 335 (8696) :1016-1020

[8] MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I-RESTRICTED T-CELLS ARE REQUIRED FOR RESISTANCE TO MYCOBACTERIUM-TUBERCULOSIS INFECTION [J].

FLYNN, JL ;

GOLDSTEIN, MM ;

TRIEBOLD, KJ ;

KOLLER, B ;

BLOOM, BR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (24) :12013-12017

[9] Isolation of Mycobacterium-reactive CD1-restricted T cells from patients with human immunodeficiency virus infection [J].

Gong, JH ;

Stenger, S ;

Zack, JA ;

Jones, BE ;

Bristol, GC ;

Modlin, RL ;

Morrissey, PJ ;

Barnes, PF .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (02) :383-389

[10] B-cell epitopes and quantification of the ESAT-6 protein of Mycobacterium tuberculosis [J].

Harboe, M ;

Malin, AS ;

Dockrell, HS ;

Wiker, HG ;

Ulvund, G ;

Holm, A ;

Jorgensen, MC ;

Andersen, P .

INFECTION AND IMMUNITY, 1998, 66 (02) :717-723