ERBB2 phosphorylation and trastuzumab sensitivity of breast cancer cell lines

被引：57

作者：

Ginestier, C.

Adelaiede, J.

Goncalves, A.

Repellini, L.

Sircoulomb, F.

Letessier, A.

Finetti, P.

Geneix, J.

Charafe-Jauffret, E.

Bertucci, F.

Jacquemier, J.

Viens, P.

Birnbaum, D.

机构：

[1] Inst J Paoli I Calmettes, Ctr Rech Cancerol Marseille, INSERM, UMR599,Dept Oncol Mol, F-13009 Marseille, France

[2] Inst J Paoli I Calmettes, Ctr Rech Cancerol Marseille, INSERM, UMR599,Dept Oncol Med, F-13009 Marseille, France

[3] Univ Mediterranee, Fac Med, Marseille, France

[4] Inst J Paoli I Calmettes, Dept BioPathol, F-13009 Marseille, France

来源：

ONCOGENE | 2007年 / 26卷 / 50期

关键词：

herceptin; trastuzumab; ERBB2; breast cancer; phosphorylation; tyrosine kinase;

D O I：

10.1038/sj.onc.1210528

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Breast cancers that overexpress the ERBB2 tyrosine kinase receptor may be treated with the recombinant humanized monoclonal anti-ERBB2 antibody trastuzumab (herceptin). However, resistance to this targeted therapy is frequent. We have determined the response of 18 breast tumor cell lines to trastuzumab and compared it with the ERBB2 phosphorylation status using antibodies directed against tyrosine residue 1248. We show that sensitivity to trastuzumab is frequently associated with the expression of a phosphorylated ERBB2 protein.

引用

页码：7163 / 7169

页数：7

共 39 条

[1]

A recurrent chromosome translocation breakpoint in breast and pancreatic cancer cell lines targets the neuregulin/NRGI gene [J].

Adélaïde, J ;

Huang, HE ;

Murati, A ;

Alsop, AE ;

Orsetti, A ;

Mozziconacci, MJ ;

Popovici, C ;

Ginestier, C ;

Letessier, A ;

Basset, C ;

Courtay-Cahen, C ;

Jacquemier, J ;

Theillet, C ;

Birnbaum, D ;

Edwards, PAW ;

Chaffanet, M .

GENES CHROMOSOMES & CANCER, 2003, 37 (04) :333-345

[2]

Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to Herceptin [J].

Anastasi, S ;

Sala, G ;

Chen, HP ;

Caprini, E ;

Russo, G ;

Iacovelli, S ;

Lucini, F ;

Ingvarsson, S ;

Segatto, O .

ONCOGENE, 2005, 24 (28) :4540-4548

[3]

BADACHE A, 2004, NAT CELL BIOL, V6, P515

[4]

Future options with trastuzumab for primary systemic and adjuvant therapy [J].

Baselga, J ;

Gianni, L ;

Geyer, C ;

Perez, EA ;

Riva, A ;

Jackisch, C .

SEMINARS IN ONCOLOGY, 2004, 31 (05) :51-57

[5]

Phase II study of efficacy, safety, and pharmacokinetics of trastuzumab monotherapy administered on a 3-weekly schedule [J].

Baselga, J ;

Carbonell, X ;

Castañeda-Soto, NJ ;

Clemens, M ;

Green, M ;

Harvey, V ;

Morales, S ;

Barton, C ;

Ghahramani, P .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (10) :2162-2171

[6]

Monoclonal antibody-based targeted therapy in breast cancer: Current status and future directions [J].

Bernard-Marty, Chantal ;

Lebrun, Fabienne ;

Awada, Ahmad ;

Piccart, Martine J. .

DRUGS, 2006, 66 (12) :1577-1591

[7]

Identification and validation of an ERBB2 gene expression signature in breast cancers [J].

Bertucci, F ;

Borie, N ;

Ginestier, C ;

Groulet, A ;

Charafe-Jauffret, E ;

Adélaïde, J ;

Geneix, J ;

Bachelart, L ;

Finetti, P ;

Koki, A ;

Hermitte, F ;

Hassoun, J ;

Debono, S ;

Viens, P ;

Fert, V ;

Jacquemier, J ;

Birnbaum, D .

ONCOGENE, 2004, 23 (14) :2564-2575

[8]

ERBIN:: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor [J].

Borg, JP ;

Marchetto, S ;

Le Bivic, A ;

Ollendorff, V ;

Jaulin-Bastard, F ;

Saito, H ;

Fournier, E ;

Adélaïde, J ;

Margolis, B ;

Birnbaum, D .

NATURE CELL BIOLOGY, 2000, 2 (07) :407-414

[9]

Gene expression profiling of breast cell lines identifies potential new basal markers [J].

Charafe-Jauffret, E ;

Ginestier, C ;

Monville, F ;

Finetti, P ;

Adélaïde, J ;

Cervera, N ;

Fekairi, S ;

Xerri, L ;

Jacquemier, J ;

Birnbaum, D ;

Bertucci, F .

ONCOGENE, 2006, 25 (15) :2273-2284

[10]

Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab [J].

Cho, HS ;

Mason, K ;

Ramyar, KX ;

Stanley, AM ;

Gabelli, SB ;

Denney, DW ;

Leahy, DJ .

NATURE, 2003, 421 (6924) :756-760

← 1 2 3 4 →