Reproductive risk factors for breast cancer in Hispanic and non-Hispanic white women - The new Mexico women's health study

被引:60
作者
Gilliland, FD
Hunt, WC
Baumgartner, KB
Crumley, D
Nicholson, CS
Fetherolf, J
Samet, JM
机构
[1] Univ So Calif, Hlth Sci Ctr, Dept Prevent Med, Div Occupat & Environm Hlth, Los Angeles, CA 90033 USA
[2] Univ New Mexico, Hlth Sci Ctr, Canc Res & Treatment Ctr, Epidemiol & Canc Control Program, Albuquerque, NM 87131 USA
[3] Univ New Mexico, Hlth Sci Ctr, Canc Res & Treatment Ctr, New Mexico Tumor Registry, Albuquerque, NM 87131 USA
[4] Univ So Calif, Hlth Sci Ctr, Kenneth Norris Jr Comprehens Canc Ctr, Los Angeles, CA 90033 USA
[5] Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Epidemiol, Baltimore, MD USA
关键词
breast neoplasm; Hispanic Americans; risk factors;
D O I
10.1093/aje/148.7.683
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
The authors conducted a population-based case-control study of breast cancer in Hispanic women in New Mexico. Hispanic and non-Hispanic white women with incident breast cancer, aged 30-74 years and diagnosed between 1992 and 1994, were identified by the New Mexico Tumor Registry. Controls were selected using random digit dialing and frequency matched by ethnicity, age, and region. Information on reproductive history, lactation, and other risk factors was collected through in-person interviews; 719 Hispanics and 836 non-Hispanic whites were included in the analysis. Conditional logistic regression was used to estimate relative risk of breast cancer for reproductive factors and to assess ethnic differences in effects. Older age at first full-term birth was associated with breast cancer among Hispanics; the odds ratio for women aged 27 years and older at first full-term birth compared with women 18 years or younger was 2.26 (95% confidence interval 1.17-4.38) compared with 1.60 (95% confidence interval 0.86-3.01) for non-Hispanic whites. Higher parity was associated with reduced risk of breast cancer for non-Hispanic whites, but not Hispanics (p < 0.008). Longer lactation was associated with reduced risk in premenopausal Hispanic women and premenopausal and postmenopausal non-Hispanic white women. Reproductive factors explained 17% of the ethnic difference in breast cancer incidence for postmenopausal women and none of the difference for premenopausal women.
引用
收藏
页码:683 / 692
页数:10
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