The dentate gyrus in Alzheimer's disease

被引：59

作者：

Ohm, Thomas G. ^{[1
]}

机构：

[1] Charite CCM, Dept Clin Cell & Neurobiol, Inst Integrat Neuroanat, D-10098 Berlin, Germany

来源：

DENTATE GYRUS: A COMPHREHENSIVE GUIDE TO STRUCTURE, FUNCTION, AND CLINICAL IMPLICATIONS | 2007年 / 163卷

关键词：

hippocampus; granule cells; interneuron; Alzheimer's disease; dentate gyrus; review;

D O I：

10.1016/S0079-6123(07)63039-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

As part of the hippocampus, the dentate gyrus is considered to play a crucial role in associative memory. The reviewed data suggest that the dentate gyrus withstands the formation of plaques, tangles and neuronal death until late stages of Alzheimer's disease (AD). However, changes related to a disconnecting process, and more subtle intrinsic alterations, may contribute to disturbances in memory and learning observed in early stages of AD.

引用

页码：723 / 740

页数：18

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