Late increase in acetaminophen concentration after overdose of Tylenol Extended Relief

被引：34

作者：

Bizovi, KE ^{[1
]}

Aks, SE ^{[1
]}

Paloucek, F ^{[1
]}

Gross, R ^{[1
]}

Keys, N ^{[1
]}

Rivas, J ^{[1
]}

机构：

[1] UNIV ILLINOIS,COOK CTY HOSP,RUSH PRESBYTERIAN ST LUKES MED CTR,TOXIKON CONSORTIUM,CHICAGO,IL 60612

来源：

ANNALS OF EMERGENCY MEDICINE | 1996年 / 28卷 / 05期

关键词：

D O I：

10.1016/S0196-0644(96)70119-1

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

We report a case demonstrating a late increase in acetaminophen concentration after ingestion of Tylenol Extended Relief (extended-release acetaminophen; McNeil Consumer Products) along with drugs known to slow gastrointestinal motility. Coingestants that slow gastrointestinal motility are known to affect the interpretation of serum drug concentrations. However, this case illustrates potentially significant differences between extended-release and immediate-release acetaminophen and demonstrates an exception to the current manufacturer recommendation for the use of the Rumack-Matthew nomogram in this setting.

引用

页码：549 / 551

页数：3

共 10 条

[1]

Cetaruk E., 1995, Journal of Toxicology Clinical Toxicology, V33, P511

[2] EFFECT OF FOOD ON ACETAMINOPHEN ABSORPTION IN YOUNG AND ELDERLY SUBJECTS [J].