Molecular views of recombination proteins and their control

被引：766

作者：

West, SC ^{[1
]}

机构：

[1] London Res Inst, Clare Hall Labs, S Mimms EN6 3LD, Herts, England

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2003年 / 4卷 / 06期

关键词：

D O I：

10.1038/nrm1127

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The efficient repair of double-strand breaks in DNA is critical for the maintenance of genome stability and cell survival. Homologous recombination provides an efficient and faithful pathway of repair, especially in replicating cells, in which it plays a major role in tumour avoidance. Many of the enzymes that are involved in recombination have been isolated, and the details of this pathway are now being unravelled at the molecular level.

引用

页码：435 / 445

页数：11

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