Aberrant expression of cdx2 homeobox gene in intraductal papillary-mucinous neoplasm of the pancreas but not in pancreatic ductal adenocarcinoma

被引：11

作者：

Yeh, TS

Ho, YP

Chiu, CT

Chen, TC

Jan, YY

Chen, MF

机构：

[1] Chang Gung Mem Hosp, Dept Surg, Taoyuan, Taiwan

[2] Chang Gung Univ, Dept Gastroenterol, Chang Gung Mem Hosp, Taipei, Taiwan

[3] Chang Gung Univ, Dept Pathol, Chang Gung Mem Hosp, Taipei, Taiwan

来源：

PANCREAS | 2005年 / 30卷 / 03期

关键词：

intraductal papillary mucinous neoplasm of the pancreas; cdx2; intestinal metaplasia;

D O I：

10.1097/01.mpa.0000153615.55761.00

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Objectives: The authors investigated differential expression of cdx2 in intraductal papillary mucinous neoplasm of the pancreas (IPMN) and ductal adenocarcinoma. Methods: Patients with IPMN (n = 23) and pancreatic ductal adenocarcinoma ( n = 30) were studied. Expression of cdx2 mRNA, CDX2 protein, muc2 mRNA, MUC2 apomucin, and MUC5AC apomucin were determined. Results: Of 23 IPMN, expression of cdx2 was detected in 8 of 9 adenomas, 6 of 8 borderline malignancies, and 3 of 6 malignancies, respectively. Of the 3 cdx2-expressing malignant IPMN, 2 did not display CDX2 expression. The appearance of CDX2-positive neoplastic cells in IPMN coincided with that of MUC2-positive neoplastic cells. All 23 IPMN displayed a positive MUC5AC expression irrespective to the status of CDX2 expression. Of 30 ductal adenocarcinomas, none displayed cdx2, CDX2, and MUC2 expression, while 10 cases displayed positive MUC5AC expression. Conclusion: Aberrant expression of cdx2 homeobox gene was detected in IPMN but not in ductal adenocarcinoma, which might determine their diverse carcinogenesis.

引用

页码：233 / 238

页数：6

共 27 条

[1] Pathologically and biologically distinct types of epithelium in intraductal papillary mucinous neoplasms - Delineation of an "Intestinal" pathway of carcinogenesis in the pancreas [J].