Sam68, the KH domain-containing superSTAR

被引：219

作者：

Lukong, KE

Richard, S

机构：

[1] Lady Davis Inst Med Res, Terry Fox Mol Oncol Grp, Montreal, PQ H3T 1E2, Canada

[2] Lady Davis Inst Med Res, Bloomfield Ctr Res Aging, Montreal, PQ H3T 1E2, Canada

[3] McGill Univ, Dept Oncol, Montreal, PQ H3T 1E2, Canada

[4] McGill Univ, Dept Med, Montreal, PQ H3T 1E2, Canada

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2003年 / 1653卷 / 02期

基金：

加拿大健康研究院;

关键词：

Sam68; signaling; RNA binding; KH domain; RNA-BINDING PROTEIN; SRC-ASSOCIATED PROTEIN; PROLINE-RICH LIGANDS; FRAGILE-X-SYNDROME; NUCLEAR-LOCALIZATION SIGNAL; FAMILY TYROSINE KINASES; CELL-CYCLE PROGRESSION; SPLICING FACTOR SF1; MESSENGER-RNA; SH3; DOMAINS;

D O I：

10.1016/j.bbcan.2003.09.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sam68 is one of the most studied members of the STAR family of RNA-binding proteins since its identification over a decade ago. Since its ascension into prominence, enormous progress has been made to unmask the link between the RNA-binding properties of Sam68 and the regulation of cellular processes including signal transduction, cell cycle regulation and tumorigenesis and RNA biogenesis in general. In this review we provide a detailed description of the functional domains of Sam68 and the possible biological roles that justify its superSTAR status. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：73 / 86

页数：14

共 110 条

[1] Regulatory intramolecular association in a tyrosine kinase of the Tec family [J].