Reversal of enantioselectivity using catalysts containing multiple stereogenic centres

被引：31

作者：

Cobb, AJA ^{[1
]}

Marson, CM ^{[1
]}

机构：

[1] UCL, Dept Chem, Christopher Ingold Labs, London WC1H 0AJ, England

来源：

TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 11期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0957-4166(01)00290-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

N-methylation of ligands with multiple stereogenic centres is shown to provide the product of the opposite configuration in significant enantiomeric excess (e.e), in the addition of diethylzinc to aldehydes. The catalysts possess stereogenic centres appended to a trans-1,2-cyclohexanediamine core. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1547 / 1550

页数：4

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