Genomic sources of regulatory variation in cis and in trans

被引：53

作者：

Wittkopp, PJ ^{[1
]}

机构：

[1] Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14853 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2005年 / 62卷 / 16期

关键词：

gene expression; regulation; cis; trans; regulatory network;

D O I：

10.1007/s00018-005-5064-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Regulatory variation results from genetic changes with both cis and trans acting effects on gene expression. Here I describe the types of genetic variants that alter cis and trans regulation and discuss differences in the potential for cis and trans changes among different classes of genes. I argue that the molecular function of the protein encoded by each gene and how the gene is wired into the genomic regulatory network may influence its propensity for cis and trans regulatory changes.

引用

页码：1779 / 1783

页数：5

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