Plasma-Diluted Thrombin Time to Measure Dabigatran Concentrations During Dabigatran Etexilate Therapy

被引:57
作者
Avecilla, Scott T. [2 ]
Ferrell, Chris
Chandler, Wayne L. [3 ]
Reyes, Morayma [1 ]
机构
[1] Univ Washington, Dept Pathol & Lab Med, Seattle, WA 98109 USA
[2] New York Blood Ctr, New York, NY 10021 USA
[3] Methodist Hosp, Dept Pathol & Lab Med, Houston, TX 77030 USA
关键词
Dabigatran; Thrombin time; Thrombin inhibitor; INHIBITOR;
D O I
10.1309/AJCPAU7OQM0SRPZQ
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
New anticoagulants, like the orally available direct thrombin inhibitor (DTI) dabigatran etexilate, have recently been introduced into the market for venous thromboembolic prophylaxis and for stroke prevention in atrial fibrillation. While dabigatran has been approved for use without the need for routine therapeutic monitoring, there are clinical scenarios in which monitoring can help guide clinical management. We report herein the application of a recently described plasma-diluted thrombin time (DTI assay) used to monitor intravenous DTI as a useful and easily implemented method to monitor oral DTIs.
引用
收藏
页码:572 / 574
页数:3
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