From endocytosis to tumors through asymmetric cell division of stem cells

被引：15

作者：

Cournailleau, Franck ^{[1
,2
]}

Gonzalez-Gaitan, Marcos ^{[1
,2
]}

机构：

[1] Univ Geneva, Dept Biochem, CH-1211 Geneva, Switzerland

[2] Univ Geneva, Dept Mol Biol, CH-1211 Geneva, Switzerland

来源：

CURRENT OPINION IN CELL BIOLOGY | 2008年 / 20卷 / 04期

关键词：

D O I：

10.1016/j.ceb.2008.03.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent studies in vertebrate and invertebrate model organisms uncover the importance of endocytosis for biased signaling during asymmetric cell division. In stem cells, perturbing polarity and asymmetric division affect their selfrenewal causing exponential proliferation, thereby giving rise to cancer. An emerging pattern is that endocytosis controls asymmetric cell division, which underlies stem cell selfrenewal and defective selfrenewal is on the basis of tumorigenesis caused by cancer stem cells.

引用

页码：462 / 469

页数：8

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