Expression of estrogen receptor alpha and beta during mouse embryogenesis

被引：118

作者：

Lemmen, JG

Broekhof, JLM

Kuiper, GGJM

Gustafsson, JA

van der Saag, PT

van der Burg, B

机构：

[1] Netherlands Inst Dev Biol, Hubrecht Lab, NL-3584 CT Utrecht, Netherlands

[2] Karolinska Inst, Ctr Biotechnol, Huddinge, Sweden

[3] Karolinska Inst, Dept Med Nutr, Huddinge, Sweden

来源：

MECHANISMS OF DEVELOPMENT | 1999年 / 81卷 / 1-2期

关键词：

estrogen receptor alpha; estrogen receptor beta; steroid hormone receptor; mouse embryogenesis; reproductive tract; mammary gland; cartilage primordia; mullerian duct; Wolffian duct; gonad; heart; midgut; larynx; kidney;

D O I：

10.1016/S0925-4773(98)00223-8

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In adult mammals numerous target tissues and organs for estrogens exist. Little is known about possible target organs during embryogenesis other than the reproductive tract and the gonads. This is the first report on the expression of estrogen receptor beta (ER beta) in comparison with ER alpha mRNA during mouse embryogenesis. We found expression of estrogen receptor mRNA in the reproductive tract, but also in the atrial wall, brain, kidney, urethra, bladder neck, mammary gland primordium, midgut, cartilage primordia and perichondria. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

收藏

页码：163 / 167

页数：5

相关论文

共 9 条

[1] A NOVEL X-GENE WITH A WIDELY TRANSCRIBED Y-LINKED HOMOLOG ESCAPES X-INACTIVATION IN MOUSE AND HUMAN [J].

AGULNIK, AI ;

MITCHELL, MJ ;

MATTEI, MG ;

BORSANI, G ;

AVNER, PA ;

LERNER, JL ;

BISHOP, CE .

HUMAN MOLECULAR GENETICS, 1994, 3 (06) :879-884

[2]

FEIJEN A, 1994, DEVELOPMENT, V120, P3621

[3] ESTROGEN-RECEPTORS, ESTRADIOL, AND DIETHYLSTILBESTROL IN EARLY DEVELOPMENT - THE MOUSE AS A MODEL FOR THE STUDY OF ESTROGEN-RECEPTORS AND ESTROGEN-SENSITIVITY IN EMBRYONIC-DEVELOPMENT OF MALE AND FEMALE REPRODUCTIVE TRACTS [J].

GRECO, TL ;

DUELLO, TM ;

GORSKI, J .

ENDOCRINE REVIEWS, 1993, 14 (01) :59-71

[4] THE ONTOGENY OF THE MOUSE ESTROGEN-RECEPTOR - THE PELVIC REGION [J].

HOLDEREGGER, C ;

KEEFER, D .

AMERICAN JOURNAL OF ANATOMY, 1986, 177 (02) :285-297

[5] Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β [J].

Kuiper, GGJM ;

Lemmen, JG ;

Carlsson, B ;

Corton, JC ;

Safe, SH ;

van der Saag, PT ;

van der Burg, P ;

Gustafsson, JÄ .

ENDOCRINOLOGY, 1998, 139 (10) :4252-4263

[6] Cloning of a novel estrogen receptor expressed in rat prostate and ovary [J].

Kuiper, GGJM ;

Enmark, E ;

PeltoHuikko, M ;

Nilsson, S ;

Gustafsson, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (12) :5925-5930

[7] ALTERATION OF REPRODUCTIVE FUNCTION BUT NOT PRENATAL SEXUAL DEVELOPMENT AFTER INSERTIONAL DISRUPTION OF THE MOUSE ESTROGEN-RECEPTOR GENE [J].

LUBAHN, DB ;

MOYER, JS ;

GOLDING, TS ;

COUSE, JF ;

KORACH, KS ;

SMITHIES, O .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (23) :11162-11166

[8] Differential ligand activation of estrogen receptors ER alpha and ER beta at AP1 sites [J].

Paech, K ;

Webb, P ;

Kuiper, GGJM ;

Nilsson, S ;

Gustafsson, JA ;

Kushner, PJ ;

Scanlan, TS .

SCIENCE, 1997, 277 (5331) :1508-1510

[9] ESTROGEN-RECEPTORS IN THE FETAL MOUSE [J].

STUMPF, WE ;

NARBAITZ, R ;

SAR, M .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1980, 12 (JAN) :55-64