Combinatorial control of protein phosphatase-1

被引：244

作者：

Bollen, M ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Fac Geneeskunde, Afdeling Biochem, B-3000 Louvain, Belgium

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2001年 / 26卷 / 07期

关键词：

D O I：

10.1016/S0968-0004(01)01836-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The catalytic subunit of the type 1 Ser/Thr protein phosphatases (PP1) can interact with many different regulatory (R) subunits. These R subunits function as activity-modulators, targeting subunits and/or substrates. The specificity of the R subunits can be accounted for by their interaction with specific subsets of binding pockets on the catalytic subunit and by the presence of subcellular targeting sequences. Hormones, growth factors and metabolites control the function of PP1 holoenzymes mainly by modulating the interaction of the subunits.

引用

页码：426 / 431

页数：6

共 45 条

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