Endometrial regenerative cells:: A novel stem cell population

被引：437

作者：

Meng, Xiaolong ^{[1
]}

Ichim, Thomas E. ^{[2
]}

Zhong, Jie ^{[1
]}

Rogers, Andrea ^{[1
]}

Yin, Zhenglian ^{[1
]}

Jackson, James ^{[1
]}

Wang, Hao ^{[3
]}

Ge, Wei ^{[3
]}

Bogin, Vladimir ^{[2
]}

Chan, Kyle W. ^{[2
]}

Thebaud, Bernard ^{[4
]}

Riordan, Neil H. ^{[1
,2
]}

机构：

[1] Biocommun Res Inst, Wichita, KS USA

[2] Medistem Labs Inc, Tempe, AZ USA

[3] Univ Western Ontario, Dept Surg, London, ON N6A 3K7, Canada

[4] Univ Alberta, Dept Pediat, Edmonton, AB, Canada

来源：

JOURNAL OF TRANSLATIONAL MEDICINE | 2007年 / 5卷 / 1期

关键词：

D O I：

10.1186/1479-5876-5-57

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Angiogenesis is a critical component of the proliferative endometrial phase of the menstrual cycle. Thus, we hypothesized that a stem cell-like population exist and can be isolated from menstrual blood. Mononuclear cells collected from the menstrual blood contained a subpopulation of adherent cells which could be maintained in tissue culture for >68 doublings and retained expression of the markers CD9, CD29, CD41a, CD44, CD59, CD73, CD90 and CD105, without karyotypic abnormalities. Proliferative rate of the cells was significantly higher than control umbilical cord derived mesenchymal stem cells, with doubling occurring every 19.4 hours. These cells, which we termed "Endometrial Regenerative Cells" (ERC) were capable of differentiating into 9 lineages: cardiomyocytic, respiratory epithelial, neurocytic, myocytic, endothelial, pancreatic, hepatic, adipocytic, and osteogenic. Additionally, ERC produced MMP3, MMP10, GM-CSF, angiopoietin-2 and PDGF-BB at 10-100,000 fold higher levels than two control cord blood derived mesenchymal stem cell lines. Given the ease of extraction and pluripotency of this cell population, we propose ERC as a novel alternative to current stem cells sources.

引用

页数：10

共 26 条

[1] Kidney side population reveals multilineage potential and renal functional capacity but also cellular heterogeneity [J].