Increased hydroxyl radicals in the hippocampus of stroke-prone spontaneously hypertensive rats during transient ischemia and recirculation

被引：24

作者：

Negishi, H

Ikeda, K

Nara, Y

Yamori, Y

机构：

[1] Kyoto Univ, Grad Sch Human & Environm Sci, Kyoto, Japan

[2] Univ E Asia, Grad Sch Integrated Sci & Art, Shimonoseki, Yamaguchi, Japan

来源：

NEUROSCIENCE LETTERS | 2001年 / 306卷 / 03期

关键词：

stroke-prone spontaneously hypertensive rats; transient ischemia; hydroxyl radicals; 2,3-dihydroxybenzoic acid;

D O I：

10.1016/S0304-3940(01)01893-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

It has been suggested that stroke-prone spontaneously hypertensive rats (SHRSP) show vulnerability to neuronal damage following transient ischemia. To observe the effect of hydroxyl radicals on neuronal damage in the hippocampus of SHRSP during ischemia and recirculation, we measured the levels of 2,3-dihydroxybenzoic acid (2,3-DHBA), as a biological marker of hydroxyl radicals in the hippocampus of SHRSP, by high pressure liquid chromatography-electrochemical detection. The production of hydroxyl radicals in the hippocampus during the first 20 min of recirculation was a peak in all intervals. The changes in 2,3-DHBA levels during ischemia and recirculation in SHRSP were significantly higher than in Wistar-Kyoto rats. These results suggest that neuronal damage following ischemia and recirculation is, in part, caused by the increase in hydroxyl radicals during ischemia and recirculation. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：206 / 208

页数：3

共 17 条

[1] OXYGEN FREE-RADICAL INVOLVEMENT IN ISCHEMIA AND REPERFUSION INJURY TO BRAIN [J].