Clinical application of nonselective assisted hatching of human embryos

Objective: To evaluate the effect of nonselective assisted hatching on pregnancy rate (PR) and to provide an alternative and simplified method for clinical application of assisted hatching. Design: Retrospective analysis of clinical data. Setting: Private infertility practice. Patient(s): Women from 258 consecutive stimulated IVF cycles. Intervention(s): Assisted hatching was performed on each transferred embryo regardless of patient history, embryo morphology, or other selection criteria routinely applied to many IVF programs. Main Outcome Measure(s): Pregnancy, live birth, and implantation rates. Result(s): Of 258 consecutive patients who had nonselective assisted hatching, 109 (42%) had clinical pregnancies, with 93 (36%) live births and 178 (20%) embryos implanted. Conclusion(s): Nonselective assisted hatching resulted in an acceptable PR and provided an alternative and simplified method for clinical application of assisted hatching.