Mucociliary clearance is enhanced in rat models of cigarette smoke and lipopolysaccharide-induced lung disease

被引：15

作者：

Coote, K ^{[1
]}

Nicholls, A ^{[1
]}

Atherton, HC ^{[1
]}

Sugar, R ^{[1
]}

Danahay, H ^{[1
]}

机构：

[1] Novartis Resp Res Ctr, Horsham, W Sussex, England

来源：

EXPERIMENTAL LUNG RESEARCH | 2004年 / 30卷 / 01期

关键词：

animal model; bronchitis; mucus hypersecretion;

D O I：

10.1080/01902140490252885

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

In. this study, the authors describe a new technique enabling the rapid assessment of mucociliary clearance (MCC) in rats and characterize this aspect of innate host defense in 2 animal models of bronchitis. Following instillation into the airways, fluorescent microspheres were rapidly cleared over 24 hours, with 60% to 80% of clearance occurring within 4 hours. On a background of airway neutrophilia and mucus hypersecretion, induced by either lipopolysaccharide or cigarette smoke, MCC was significantly enhanced. This reserve capacity in the MCC system will need to become overwhelmed in order to model the clinically observed, impairment of lung mucus clearance in an animal system.

引用

页码：59 / 71

页数：13

共 35 条

[1] DURATION OF MUCOCILIARY DYSFUNCTION FOLLOWING ANTIGEN CHALLENGE [J].