Inhibition of natural killer (NK) cell activity against varicella-zoster virus (VZV)-infected fibroblasts and lymphocyte activation in response to VZV antigen by nitric oxide-releasing agents

被引：11

作者：

Ito, M ^{[1
]}

Watanabe, M ^{[1
]}

Kamiya, H ^{[1
]}

Sakurai, M ^{[1
]}

机构：

[1] MIE NATL HOSP,DEPT PAEDIAT,TSU,MIE,JAPAN

来源：

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 1996年 / 106卷 / 01期

关键词：

varicella zoster virus; natural killer cell; nitric oxide;

D O I：

10.1046/j.1365-2249.1996.d01-807.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The addition of nitric oxide (NO)-releasing agents, S-nitroso-N-acetyl-DL-penicillamine (SNAP), 1-hydroxy-2-oxo-2,3-bis(2-aminoethyl)-1-triazene (NOC18), 30{(+/-)-(E)-ethyl-2'-[(E)-hydroxy-imino]-5-nitro-3-hexenecarbamoyl}-pyridine (NOR4) significantly inhibited NK cell activity against VZV-infected cells, while antibody-dependent cell-mediated cytotoxicity (ADCC) against VZV-infected cells was unaffected. Interferon-alpha (IFN-alpha) production by non-adherent peripheral blood mononuclear cells (NPBMC) cultured with VZV-infected cells was decreased by the addition of NO-releasing agents. Lymphocyte proliferation and the expression IL-2 receptor (CD25) in response to VZV antigen were also inhibited by the addition of NO-releasing agents. These results suggest that the production of NO by an inflammatory process may lead to inhibition of NK cell- and T cell-mediated immunity to VZV infection.

引用

页码：40 / 44

页数：5

共 15 条

[1] REQUIREMENT FOR HLA-DR+ ACCESSORY CELLS IN NATURAL KILLING OF CYTOMEGALOVIRUS-INFECTED FIBROBLASTS [J].