共 21 条
Fractions of chemically oversulphated galactosaminoglycan sulphates inhibit three enveloped viruses: human immunodeficiency virus type 1, herpes simplex virus type 1 and human cytomegalovirus
被引:12
作者:

Di Caro, A
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机构: CNR, Ist Strutturist Chim G Giacomello, I-00016 Monterotondo, Roma, Italy

Perola, E
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机构: CNR, Ist Strutturist Chim G Giacomello, I-00016 Monterotondo, Roma, Italy

Bartolini, B
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机构: CNR, Ist Strutturist Chim G Giacomello, I-00016 Monterotondo, Roma, Italy

Marzano, M
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机构: CNR, Ist Strutturist Chim G Giacomello, I-00016 Monterotondo, Roma, Italy

Liverani, L
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机构: CNR, Ist Strutturist Chim G Giacomello, I-00016 Monterotondo, Roma, Italy

Mascellani, G
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机构: CNR, Ist Strutturist Chim G Giacomello, I-00016 Monterotondo, Roma, Italy

Benedetto, A
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机构: CNR, Ist Strutturist Chim G Giacomello, I-00016 Monterotondo, Roma, Italy

Cellai, L
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机构: CNR, Ist Strutturist Chim G Giacomello, I-00016 Monterotondo, Roma, Italy
机构:
[1] CNR, Ist Strutturist Chim G Giacomello, I-00016 Monterotondo, Roma, Italy
[2] IRCCS L Spallanzani, Ctr Virol, I-00149 Rome, Italy
[3] OPOCRIN, I-41040 Modena, Italy
关键词:
oversulphated chondroitins;
oversulphated dermatans;
HIV;
HSV;
HCMV;
AIDS;
D O I:
10.1177/095632029901000104
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
A series of chemically oversulphated galactosaminoglycans (SO3H:COOH ratio greater than or equal to 2) were tested in vitro as antiviral agents against human immunodeficiency virus type 1 (HIV-1), the aetiological agent of AIDS, and against herpes simplex virus type 1 and human cytomegalovirus, two agents responsible for opportunistic infections in HIV-infected people. The oversulphated derivatives displayed an increase in activity ranging from one to four orders of magnitude against the three viruses, as compared to the natural parent compounds (SO3H:COOH, ratio approx. I). The antiviral activity of these polyanions appears to be favoured by a high degree of sulphation and a high molecular mass. An oversulphated dermatan, with a SO3H:COOH ratio of 2.86 and molecular mass of 23.2 kDa, was the most potent anti-HIV-l compound (EC50 0.04 mu g/ml). A second oversulphated dermatan, with a SO3H:COOH ratio of 2.40 and molecular mass of 25 kDa, displayed the highest activity against HSV-1 (EC50 0.01 mu g/ml). An oversulphated chondroitin, with a SO3H:COOH ratio of 2.80 and molecular mass of 17.3 kDa, was the strongest anti-HCMV agent (EC50 0.4 mu g/ml). In view of the absence of the side-effects typical of heparin-like compounds, a combination of these derivatives could have therapeutic potential.
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页码:33 / 38
页数:6
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共 21 条
[1]
PENTOSAN POLYSULFATE, A SULFATED OLIGOSACCHARIDE, IS A POTENT AND SELECTIVE ANTI-HIV AGENT INVITRO
[J].
BABA, M
;
NAKAJIMA, M
;
SCHOLS, D
;
PAUWELS, R
;
BALZARINI, J
;
DECLERCQ, E
.
ANTIVIRAL RESEARCH,
1988, 9 (06)
:335-343

BABA, M
论文数: 0 引用数: 0
h-index: 0
机构: CATHOLIC UNIV LEUVEN,REGA INST MED RES,DEPT HUMAN BIOL,DIV MICROBIOL,MINDERBROEDERSSTR 10,B-3000 LOUVAIN,BELGIUM

NAKAJIMA, M
论文数: 0 引用数: 0
h-index: 0
机构: CATHOLIC UNIV LEUVEN,REGA INST MED RES,DEPT HUMAN BIOL,DIV MICROBIOL,MINDERBROEDERSSTR 10,B-3000 LOUVAIN,BELGIUM

SCHOLS, D
论文数: 0 引用数: 0
h-index: 0
机构: CATHOLIC UNIV LEUVEN,REGA INST MED RES,DEPT HUMAN BIOL,DIV MICROBIOL,MINDERBROEDERSSTR 10,B-3000 LOUVAIN,BELGIUM

PAUWELS, R
论文数: 0 引用数: 0
h-index: 0
机构: CATHOLIC UNIV LEUVEN,REGA INST MED RES,DEPT HUMAN BIOL,DIV MICROBIOL,MINDERBROEDERSSTR 10,B-3000 LOUVAIN,BELGIUM

BALZARINI, J
论文数: 0 引用数: 0
h-index: 0
机构: CATHOLIC UNIV LEUVEN,REGA INST MED RES,DEPT HUMAN BIOL,DIV MICROBIOL,MINDERBROEDERSSTR 10,B-3000 LOUVAIN,BELGIUM

DECLERCQ, E
论文数: 0 引用数: 0
h-index: 0
机构: CATHOLIC UNIV LEUVEN,REGA INST MED RES,DEPT HUMAN BIOL,DIV MICROBIOL,MINDERBROEDERSSTR 10,B-3000 LOUVAIN,BELGIUM
[2]
MECHANISM OF INHIBITORY EFFECT OF DEXTRAN SULFATE AND HEPARIN ON REPLICATION OF HUMAN IMMUNODEFICIENCY VIRUS INVITRO
[J].
BABA, M
;
PAUWELS, R
;
BALZARINI, J
;
ARNOUT, J
;
DESMYTER, J
;
DECLERCQ, E
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1988, 85 (16)
:6132-6136

BABA, M
论文数: 0 引用数: 0
h-index: 0
机构:
CTR THROMBOSIS & VASC RES,B-3000 LEUVEN,BELGIUM CTR THROMBOSIS & VASC RES,B-3000 LEUVEN,BELGIUM

PAUWELS, R
论文数: 0 引用数: 0
h-index: 0
机构:
CTR THROMBOSIS & VASC RES,B-3000 LEUVEN,BELGIUM CTR THROMBOSIS & VASC RES,B-3000 LEUVEN,BELGIUM

BALZARINI, J
论文数: 0 引用数: 0
h-index: 0
机构:
CTR THROMBOSIS & VASC RES,B-3000 LEUVEN,BELGIUM CTR THROMBOSIS & VASC RES,B-3000 LEUVEN,BELGIUM

ARNOUT, J
论文数: 0 引用数: 0
h-index: 0
机构:
CTR THROMBOSIS & VASC RES,B-3000 LEUVEN,BELGIUM CTR THROMBOSIS & VASC RES,B-3000 LEUVEN,BELGIUM

DESMYTER, J
论文数: 0 引用数: 0
h-index: 0
机构:
CTR THROMBOSIS & VASC RES,B-3000 LEUVEN,BELGIUM CTR THROMBOSIS & VASC RES,B-3000 LEUVEN,BELGIUM

DECLERCQ, E
论文数: 0 引用数: 0
h-index: 0
机构:
CTR THROMBOSIS & VASC RES,B-3000 LEUVEN,BELGIUM CTR THROMBOSIS & VASC RES,B-3000 LEUVEN,BELGIUM
[3]
INHIBITION OF HUMAN-LEUKOCYTE ELASTASE BY CHEMICALLY AND NATURALLY OVERSULFATED GALACTOSAMINOGLYCANS
[J].
BARTOLUCCI, C
;
CELLAI, L
;
IANNELLI, MA
;
LAMBA, D
;
LIVERANI, L
;
MASCELLANI, G
;
PEROLA, E
.
CARBOHYDRATE RESEARCH,
1995, 276 (02)
:401-408

BARTOLUCCI, C
论文数: 0 引用数: 0
h-index: 0
机构: CNR,IST STRUTTURIST CHIM G GIACOMELLO,I-00016 MONTEROTONDO,ITALY

CELLAI, L
论文数: 0 引用数: 0
h-index: 0
机构: CNR,IST STRUTTURIST CHIM G GIACOMELLO,I-00016 MONTEROTONDO,ITALY

IANNELLI, MA
论文数: 0 引用数: 0
h-index: 0
机构: CNR,IST STRUTTURIST CHIM G GIACOMELLO,I-00016 MONTEROTONDO,ITALY

LAMBA, D
论文数: 0 引用数: 0
h-index: 0
机构: CNR,IST STRUTTURIST CHIM G GIACOMELLO,I-00016 MONTEROTONDO,ITALY

LIVERANI, L
论文数: 0 引用数: 0
h-index: 0
机构: CNR,IST STRUTTURIST CHIM G GIACOMELLO,I-00016 MONTEROTONDO,ITALY

MASCELLANI, G
论文数: 0 引用数: 0
h-index: 0
机构: CNR,IST STRUTTURIST CHIM G GIACOMELLO,I-00016 MONTEROTONDO,ITALY

PEROLA, E
论文数: 0 引用数: 0
h-index: 0
机构: CNR,IST STRUTTURIST CHIM G GIACOMELLO,I-00016 MONTEROTONDO,ITALY
[4]
H-1-NMR INVESTIGATION OF NATURALLY-OCCURRING AND CHEMICALLY OVERSULPHATED DERMATAN SULFATES - IDENTIFICATION OF MINOR MONOSACCHARIDE RESIDUES
[J].
BOSSENNEC, V
;
PETITOU, M
;
PERLY, B
.
BIOCHEMICAL JOURNAL,
1990, 267 (03)
:625-630

BOSSENNEC, V
论文数: 0 引用数: 0
h-index: 0
机构: CENS,DEPT PHYSICOCHIM,IRDI,DESICP,F-91191 GIF SUR YVETTE,FRANCE

PETITOU, M
论文数: 0 引用数: 0
h-index: 0
机构: CENS,DEPT PHYSICOCHIM,IRDI,DESICP,F-91191 GIF SUR YVETTE,FRANCE

PERLY, B
论文数: 0 引用数: 0
h-index: 0
机构: CENS,DEPT PHYSICOCHIM,IRDI,DESICP,F-91191 GIF SUR YVETTE,FRANCE
[5]
QUANTIFICATION OF HUMAN CYTOMEGALOVIRUS VIREMIA BY USING MONOCLONAL-ANTIBODIES TO DIFFERENT VIRAL-PROTEINS
[J].
GERNA, G
;
REVELLO, MG
;
PERCIVALLE, E
;
ZAVATTONI, M
;
PAREA, M
;
BATTAGLIA, M
.
JOURNAL OF CLINICAL MICROBIOLOGY,
1990, 28 (12)
:2681-2688

GERNA, G
论文数: 0 引用数: 0
h-index: 0
机构:
CNR,INST EXPTL MED,I-00137 ROME,ITALY CNR,INST EXPTL MED,I-00137 ROME,ITALY

REVELLO, MG
论文数: 0 引用数: 0
h-index: 0
机构:
CNR,INST EXPTL MED,I-00137 ROME,ITALY CNR,INST EXPTL MED,I-00137 ROME,ITALY

PERCIVALLE, E
论文数: 0 引用数: 0
h-index: 0
机构:
CNR,INST EXPTL MED,I-00137 ROME,ITALY CNR,INST EXPTL MED,I-00137 ROME,ITALY

ZAVATTONI, M
论文数: 0 引用数: 0
h-index: 0
机构:
CNR,INST EXPTL MED,I-00137 ROME,ITALY CNR,INST EXPTL MED,I-00137 ROME,ITALY

PAREA, M
论文数: 0 引用数: 0
h-index: 0
机构:
CNR,INST EXPTL MED,I-00137 ROME,ITALY CNR,INST EXPTL MED,I-00137 ROME,ITALY

BATTAGLIA, M
论文数: 0 引用数: 0
h-index: 0
机构:
CNR,INST EXPTL MED,I-00137 ROME,ITALY CNR,INST EXPTL MED,I-00137 ROME,ITALY
[6]
Heparin and its derivatives bind to HIV-1 recombinant envelope glycoproteins, rather than to recombinant HIV-1 receptor, CD4
[J].
Harrop, HA
;
Rider, CC
.
GLYCOBIOLOGY,
1998, 8 (02)
:131-137

Harrop, HA
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Royal Holloway & Bedford New Coll, Div Biochem, Surrey TW20 0EX, England Univ London Royal Holloway & Bedford New Coll, Div Biochem, Surrey TW20 0EX, England

Rider, CC
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Royal Holloway & Bedford New Coll, Div Biochem, Surrey TW20 0EX, England Univ London Royal Holloway & Bedford New Coll, Div Biochem, Surrey TW20 0EX, England
[7]
INHIBITORY EFFECT OF DEXTRAN SULFATE AND HEPARIN ON THE REPLICATION OF HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) INVITRO
[J].
ITO, M
;
BABA, M
;
SATO, A
;
PAUWELS, R
;
DECLERCQ, E
;
SHIGETA, S
.
ANTIVIRAL RESEARCH,
1987, 7 (06)
:361-367

ITO, M
论文数: 0 引用数: 0
h-index: 0
机构:
CATHOLIC UNIV LEUVEN, REGA INST MED RES, B-3030 Heverlee, BELGIUM CATHOLIC UNIV LEUVEN, REGA INST MED RES, B-3030 Heverlee, BELGIUM

BABA, M
论文数: 0 引用数: 0
h-index: 0
机构:
CATHOLIC UNIV LEUVEN, REGA INST MED RES, B-3030 Heverlee, BELGIUM CATHOLIC UNIV LEUVEN, REGA INST MED RES, B-3030 Heverlee, BELGIUM

SATO, A
论文数: 0 引用数: 0
h-index: 0
机构:
CATHOLIC UNIV LEUVEN, REGA INST MED RES, B-3030 Heverlee, BELGIUM CATHOLIC UNIV LEUVEN, REGA INST MED RES, B-3030 Heverlee, BELGIUM

PAUWELS, R
论文数: 0 引用数: 0
h-index: 0
机构:
CATHOLIC UNIV LEUVEN, REGA INST MED RES, B-3030 Heverlee, BELGIUM CATHOLIC UNIV LEUVEN, REGA INST MED RES, B-3030 Heverlee, BELGIUM

DECLERCQ, E
论文数: 0 引用数: 0
h-index: 0
机构:
CATHOLIC UNIV LEUVEN, REGA INST MED RES, B-3030 Heverlee, BELGIUM CATHOLIC UNIV LEUVEN, REGA INST MED RES, B-3030 Heverlee, BELGIUM

SHIGETA, S
论文数: 0 引用数: 0
h-index: 0
机构:
CATHOLIC UNIV LEUVEN, REGA INST MED RES, B-3030 Heverlee, BELGIUM CATHOLIC UNIV LEUVEN, REGA INST MED RES, B-3030 Heverlee, BELGIUM
[8]
INVITRO ANTI-HIV-1 ACTIVITY OF CHONDROITIN POLYSULFATE
[J].
JURKIEWICZ, E
;
PANSE, P
;
JENTSCH, KD
;
HARTMANN, H
;
HUNSMANN, G
.
AIDS,
1989, 3 (07)
:423-427

JURKIEWICZ, E
论文数: 0 引用数: 0
h-index: 0
机构:
LUITPOLD WERKES,CHEM PHARMAZEUT FABRIK,D-8000 MUNICH 70,FED REP GER LUITPOLD WERKES,CHEM PHARMAZEUT FABRIK,D-8000 MUNICH 70,FED REP GER

PANSE, P
论文数: 0 引用数: 0
h-index: 0
机构:
LUITPOLD WERKES,CHEM PHARMAZEUT FABRIK,D-8000 MUNICH 70,FED REP GER LUITPOLD WERKES,CHEM PHARMAZEUT FABRIK,D-8000 MUNICH 70,FED REP GER

JENTSCH, KD
论文数: 0 引用数: 0
h-index: 0
机构:
LUITPOLD WERKES,CHEM PHARMAZEUT FABRIK,D-8000 MUNICH 70,FED REP GER LUITPOLD WERKES,CHEM PHARMAZEUT FABRIK,D-8000 MUNICH 70,FED REP GER

HARTMANN, H
论文数: 0 引用数: 0
h-index: 0
机构:
LUITPOLD WERKES,CHEM PHARMAZEUT FABRIK,D-8000 MUNICH 70,FED REP GER LUITPOLD WERKES,CHEM PHARMAZEUT FABRIK,D-8000 MUNICH 70,FED REP GER

HUNSMANN, G
论文数: 0 引用数: 0
h-index: 0
机构:
LUITPOLD WERKES,CHEM PHARMAZEUT FABRIK,D-8000 MUNICH 70,FED REP GER LUITPOLD WERKES,CHEM PHARMAZEUT FABRIK,D-8000 MUNICH 70,FED REP GER
[9]
Polyanion inhibitors of human immunodeficiency virus and other viruses .2. Polymerized anionic surfactants derived from amino acids and dipeptides
[J].
Leydet, A
;
ElHachemi, H
;
Boyer, B
;
Lamaty, G
;
Roque, JP
;
Schols, D
;
Snoeck, R
;
Andrei, G
;
Ikeda, S
;
Neyts, J
;
Reymen, D
;
Este, J
;
Witvrouw, M
;
DeClercq, E
.
JOURNAL OF MEDICINAL CHEMISTRY,
1996, 39 (08)
:1626-1634

Leydet, A
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MONTPELLIER 2,LAB CHIM ORGAN PHYS,F-34095 MONTPELLIER 5,FRANCE

ElHachemi, H
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MONTPELLIER 2,LAB CHIM ORGAN PHYS,F-34095 MONTPELLIER 5,FRANCE

Boyer, B
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MONTPELLIER 2,LAB CHIM ORGAN PHYS,F-34095 MONTPELLIER 5,FRANCE

Lamaty, G
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MONTPELLIER 2,LAB CHIM ORGAN PHYS,F-34095 MONTPELLIER 5,FRANCE

Roque, JP
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MONTPELLIER 2,LAB CHIM ORGAN PHYS,F-34095 MONTPELLIER 5,FRANCE

Schols, D
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MONTPELLIER 2,LAB CHIM ORGAN PHYS,F-34095 MONTPELLIER 5,FRANCE

Snoeck, R
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MONTPELLIER 2,LAB CHIM ORGAN PHYS,F-34095 MONTPELLIER 5,FRANCE

Andrei, G
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MONTPELLIER 2,LAB CHIM ORGAN PHYS,F-34095 MONTPELLIER 5,FRANCE

Ikeda, S
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MONTPELLIER 2,LAB CHIM ORGAN PHYS,F-34095 MONTPELLIER 5,FRANCE

Neyts, J
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MONTPELLIER 2,LAB CHIM ORGAN PHYS,F-34095 MONTPELLIER 5,FRANCE

Reymen, D
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MONTPELLIER 2,LAB CHIM ORGAN PHYS,F-34095 MONTPELLIER 5,FRANCE

Este, J
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MONTPELLIER 2,LAB CHIM ORGAN PHYS,F-34095 MONTPELLIER 5,FRANCE

Witvrouw, M
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MONTPELLIER 2,LAB CHIM ORGAN PHYS,F-34095 MONTPELLIER 5,FRANCE

DeClercq, E
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MONTPELLIER 2,LAB CHIM ORGAN PHYS,F-34095 MONTPELLIER 5,FRANCE
[10]
ACTIVE-SITES OF DERMATAN SULFATE FOR HEPARIN-COFACTOR-II - ISOLATION OF A NONASACCHARIDE FRAGMENT CONTAINING 4 DISACCHARIDE SEQUENCES [ALPHA-L-IDURONIC ACID 2-O-SULFATE (1,3)-BETA-D-N-ACETYLGALACTOSAMINE 4-SULFATE]
[J].
MASCELLANI, G
;
LIVERANI, L
;
PRETE, A
;
BERGONZINI, GL
;
BIANCHINI, P
;
SILVESTRO, L
;
TORRI, G
;
BISIO, A
;
GUERRINI, M
;
CASU, B
.
JOURNAL OF CARBOHYDRATE CHEMISTRY,
1995, 14 (08)
:1165-1177

MASCELLANI, G
论文数: 0 引用数: 0
h-index: 0
机构: RES PHARMA PHARMACOL RES SRL,TURIN,ITALY

LIVERANI, L
论文数: 0 引用数: 0
h-index: 0
机构: RES PHARMA PHARMACOL RES SRL,TURIN,ITALY

PRETE, A
论文数: 0 引用数: 0
h-index: 0
机构: RES PHARMA PHARMACOL RES SRL,TURIN,ITALY

BERGONZINI, GL
论文数: 0 引用数: 0
h-index: 0
机构: RES PHARMA PHARMACOL RES SRL,TURIN,ITALY

BIANCHINI, P
论文数: 0 引用数: 0
h-index: 0
机构: RES PHARMA PHARMACOL RES SRL,TURIN,ITALY

SILVESTRO, L
论文数: 0 引用数: 0
h-index: 0
机构: RES PHARMA PHARMACOL RES SRL,TURIN,ITALY

TORRI, G
论文数: 0 引用数: 0
h-index: 0
机构: RES PHARMA PHARMACOL RES SRL,TURIN,ITALY

BISIO, A
论文数: 0 引用数: 0
h-index: 0
机构: RES PHARMA PHARMACOL RES SRL,TURIN,ITALY

GUERRINI, M
论文数: 0 引用数: 0
h-index: 0
机构: RES PHARMA PHARMACOL RES SRL,TURIN,ITALY

CASU, B
论文数: 0 引用数: 0
h-index: 0
机构: RES PHARMA PHARMACOL RES SRL,TURIN,ITALY