Microwave-Assisted Hydrogel Synthesis: A New Method for Crosslinking Polymers in Aqueous Solutions

被引：72

作者：

Cook, Joseph P. ^{[1
]}

Goodall, Glenn W. ^{[1
]}

Khutoryanskaya, Olga V. ^{[1
]}

Khutoryanskiy, Vitaliy V. ^{[1
]}

机构：

[1] Univ Reading, Sch Chem Food & Pharm, Reading Sch Pharm, Reading RG6 6AD, Berks, England

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2012年 / 33卷 / 04期

基金：

英国生物技术与生命科学研究理事会;

关键词：

biomaterials; crosslinking; hydrogels; microwaves; synthesis; RING-OPENING POLYMERIZATION; RADICAL POLYMERIZATION; POLY(ACRYLIC ACID); DRUG-DELIVERY; VINYL ETHER; ALCOHOL); METHACRYLATE; STYRENE; COPOLYMERIZATIONS; IRRADIATION;

D O I：

10.1002/marc.201100742

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 [高分子化学与物理];

摘要：

It has been found that hydrogels may be formed by microwave irradiation of aqueous solutions containing appropriate combinations of polymers. This new method of hydrogel synthesis yields sterile hydrogels without the use of monomers, eliminating the need for the removal of unreacted species from the final product. Results for two particularly successful combinations, poly(vinyl alcohol) with either poly(acrylic acid) or poly(methylvinylether-alt-maleic anhydride), are presented. Irradiation using temperatures of 100-150 degrees C was found to yield hydrogels with large equilibrium swelling degrees of 500-1000 g g(-1). Material leached from both types of hydrogel shows little cytotoxicity towards HT29 cells.

引用

页码：332 / 336

页数：5

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