Programmed cellular response to ionizing radiation damage

被引:26
作者
Crompton, NEA [1 ]
机构
[1] Paul Scherrer Inst, Dept Radiat Med, CH-5232 Villigen, Switzerland
关键词
D O I
10.1080/028418698429685
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Three forms of radiation response were investigated to evaluate the hypothesis that cellular radiation response is the result of active molecular signaling and not simply a passive physicochemical process. The decision whether or not a cell should respond to radiation-induced damage either by induction of rescue systems, e.g. mobilization of repair proteins, or induction of suicide mechanisms; e.g. programmed cell death, appears to be the expression of intricate cellular biochemistry. A cell must recognize damage in its genetic material and then activate the appropriate responses. Cell type is important; the response of a fibroblast to radiation damage is both quantitatively and qualitatively different from that of a lymphocyte. The programmed component of radiation response is significant in radiation oncology and predicted to create unique opportunities for enhanced treatment success.
引用
收藏
页码:129 / 142
页数:14
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